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| http://dx.doi.org/10.1016/j.bpj.2020.07.037 | DOI Listing |
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Ion Hydration Enables Generality in Asymmetric Catalysis: Desymmetrization to P-Stereogenic Triarylphosphine Derivatives.
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National University of Singapore Department of Chemistry, Department of Chemistry, 3 Science Drive 3, 117543, Singapore, SINGAPORE.
Asymmetric synthesis relies on seamless transmission of stereochemical information from a chiral reagent/catalyst to a prochiral substrate. The disruption by substrates' structural changes presents a hurdle in innovating generality-oriented asymmetric catalysis. Here, we report a strategy for substrate adaptability by exploiting a fundamental physicochemical phenomenon-ion hydration, in developing remote desymmetrization to access P-stereogenic triarylphosphine oxides and sulfides.
View Article and Find Full Text PDFSelective hydroxylation of benzene to phenol Cu(μ-O˙)Cu intermediate using a nonsymmetric dicopper catalyst.
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Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China.
The one-step oxidation of benzene to phenol represents a significant and promising advancement in modern industries focused on the production of high-value-added chemical products. Nevertheless, challenges persist in achieving sufficient catalytic selectivity and preventing over-oxidation. Inspired by copper enzymes, we present a nonsymmetric dicopper complex ([CuII2(TPMAN)(μ-OH)(HO)], 1) for the selective oxidation of benzene to phenol.
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View Article and Find Full Text PDFUtilizing Alkyne-Nitrone Cycloaddition for the Convenient Multi-Component Assembly of Protein Degraders and Biological Probes.
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Article Synopsis
- Proteolysis-targeting chimeras (PROTACs) are emerging as a key therapeutic strategy, but synthesizing multi-functional PROTACs is complex due to traditional methods being limited to two-component reactions.
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The widespread use of synthetic dyes has led to the release of substantial amounts of dye-contaminated wastewater, posing significant environmental and health concerns. This study focuses on the use of anodic and electrochemically activated persulfate oxidation for the degradation of organic contaminants. Specifically, the structural variations of nine dyes in the indigoid and azo families, and their impact on the efficiency of electrochemical oxidation were analysed.
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