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Glial cells undergo rapid changes following acute chemogenetic manipulation of cortical layer 5 projection neurons.
Commun Biol
October 2024
Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.
Article Synopsis
- Bidirectional communication between neurons and glial cells is essential for proper brain function, but the effects of sudden changes in neuronal activity on these interactions are not well understood.
- In this study, researchers used a technique called DREADD to manipulate specific neuron populations in mouse brains, discovering that activating neurons leads to reduced synaptic density and increased glial cell reactivity, while silencing them has the opposite effect.
- The findings highlight rapid and dynamic interactions between neurons and glial cells that are influenced by neuronal activity, contributing to our understanding of brain function and potential implications for neurological conditions.
Layer 6b controls brain state via apical dendrites and the higher-order thalamocortical system.
Neuron
March 2024
Department of Biology, Humboldt Universität zu Berlin, Berlin 10117, Germany. Electronic address:
The deepest layer of the cortex (layer 6b [L6b]) contains relatively few neurons, but it is the only cortical layer responsive to the potent wake-promoting neuropeptide orexin/hypocretin. Can these few neurons significantly influence brain state? Here, we show that L6b-photoactivation causes a surprisingly robust enhancement of attention-associated high-gamma oscillations and population spiking while abolishing slow waves in sleep-deprived mice. To explain this powerful impact on brain state, we investigated L6b's synaptic output using optogenetics, electrophysiology, and monoCaTChR ex vivo.
View Article and Find Full Text PDFA subpopulation of L6b neurons provides driver-like input to the posteromedial thalamus.
J Physiol
December 2020
Department of Pharmacology, University of Oxford, Oxford, UK.
Is Expressed in Subplate Neurons With Unilateral Long-Range Inter-Areal Projections.
Front Neuroanat
May 2019
Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Subplate (SP) neurons are among the earliest-born neurons in the cerebral cortex and heterogeneous in terms of gene expression. SP neurons consist mainly of projection neurons, which begin to extend their axons to specific target areas very early during development. However, the relationships between axon projection and gene expression patterns of the SP neurons, and their remnant layer 6b (L6b) neurons, are largely unknown.
View Article and Find Full Text PDFSubset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice.
Cereb Cortex
May 2018
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
The thalamus receives input from 3 distinct cortical layers, but input from only 2 of these has been well characterized. We therefore investigated whether the third input, derived from layer 6b, is more similar to the projections from layer 6a or layer 5. We studied the projections of a restricted population of deep layer 6 cells ("layer 6b cells") taking advantage of the transgenic mouse Tg(Drd1a-cre)FK164Gsat/Mmucd (Drd1a-Cre), that selectively expresses Cre-recombinase in a subpopulation of layer 6b neurons across the entire cortical mantle.
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