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Rationale: To examine the acute effects of ayahuasca use and their relationship to sub-acute changes in affect and mindfulness in a non-clinical sample, addressing the need for a better understanding of ayahuasca's immediate and short-term impacts as interest in its use grows.

Objectives: Using prospective ecological assessment, this study investigates how ayahuasca used at a 4-day retreat affects positive/negative affect and mindfulness skills in daily living compared to pre-retreat. Additionally, we explore acute psychedelic experiences during the ayahuasca retreat, assessed retrospectively 1-2 days post-retreat, as potential mechanisms for theorized effects in daily living post-retreat.

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Death Anxiety Among Users and Non-Users of Psychedelics.

J Psychoactive Drugs

January 2025

Interdisciplinary Cooperation for Ayahuasca Research and Outreach (ICARO), School of Medical Sciences, State University of Campinas, Campinas, Brazil.

This study is a survey-type, cross-sectional study conducted in Brazil ( = 517), with online data collection taking place from April to June 2022. The main objective of this study was to evaluate the death anxiety in users and non-users of psychedelics. To this end, we also assessed the validity and reliability of the Death Anxiety Scale in Brazil.

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Emerging evidence indicates that ayahuasca consumption may have beneficial mental health effects. This study undertakes the largest analysis to date of associations between naturalistic ayahuasca use and current mental health status via an online cross-sectional survey. The sample included 7,576 participants (average age 41, 47% female) who had consumed ayahuasca in religious, traditional, or non-traditional settings in over 50 countries.

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Background/aims: While most psychedelic substances are considered to carry a relatively low risk of acute or long-term harm, co-use with other psychoactive substances may increase health and social harm. Using a large international survey of adults who use psychedelics, we sought to comprehensively characterize psychedelic co-use.

Methods: We used data from the 2023 Global Psychedelic Survey, a web-based survey of adults ⩾21 with lifetime use of psychedelics.

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Inhaled Dimethyltryptamine (DMT): Use Patterns and Predictors of Consumption Frequency.

J Psychoactive Drugs

October 2024

Department of Psychology, University at Albany, State University of New York, Albany, NY, USA.

Article Synopsis
  • - Despite growing interest in psychedelics, research on inhaled DMT is limited; a study with nearly 400 participants highlighted motivations for use, sources, and risk perceptions surrounding inhaled DMT.
  • - Most users reported beginning their DMT journey out of curiosity or interest in psychedelics, often acquiring DMT through friends and using it alone or in small groups, with glass pipes being the preferred method of inhalation.
  • - While many users described positive psychological experiences from inhaling DMT, they also faced challenges like difficult integration and "bad trips," emphasizing the need for more research and education on its safe use and potential benefits.
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