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Atypical Presentations of Hydroxychloroquine Retinopathy: A Case Series Study.
J Clin Med
June 2024
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
Hydroxychloroquine retinopathy, traditionally characterized by parafoveal or pericentral outer retinal damage, is explored for atypical presentations in Asian patients. This challenges conventional beliefs regarding onset, retinopathy pattern, and associated visual field defects. Ninety-five patients diagnosed with hydroxychloroquine retinopathy at Hanyang University Hospital underwent screening from January 2010 to December 2023.
View Article and Find Full Text PDFLaboratory features and pharmacological management of early and late-onset primary Sjögren's syndrome.
Rheumatol Int
July 2024
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Background: Primary Sjögren's Syndrome (pSS) is a systemic chronic autoimmune disorder that contributes to dry mouth (xerostomia) and eyes (xerophthalmia). It mainly affects females between 40 and 60 years old. So far, there is no treatment to cure SS; however, there is a list of medications that can ameliorate the symptoms.
View Article and Find Full Text PDF[Analyses of the risk factors for the progression of primary antiphospholipid syndrome to systemic lupus erythematosus].
Zhonghua Nei Ke Za Zhi
February 2024
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.
Article Synopsis
- - This study examined 262 patients diagnosed with primary antiphospholipid syndrome (PAPS) to determine the clinical features and risk factors related to those who progressed to systemic lupus erythematosus (SLE).
- - Among the patients, 5% (13 individuals) transitioned from PAPS to SLE, with significant risk factors identified including cardiac valve disease, positive anti-double-stranded DNA antibodies, and low levels of complement C3 and C4.
- - The findings showed that patients with two or more risk factors had a much higher chance of progressing to SLE, and treatments like hydroxychloroquine did not seem to affect this progression.
Case Report: Methotrexate and hydroxychloroquine in combination for the treatment of NOD2-mutation-associated Blau syndrome.
Front Immunol
November 2023
Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Mutations in nucleotide binding oligomerization domain containing 2 receptor (NOD2) are associated with Blau syndrome (also known as early-onset sarcoidosis)-a rare autosomal dominant, chronic granulomatous disease that typically presents before 5 years of age. Blau syndrome is characterized by the clinical triad of arthritis, granulomatous dermatitis, and recurrent uveitis. Here, we report a case of NOD2-mutation-associated early-onset sarcoidosis in which a combination of methotrexate and hydroxychloroquine was used to achieve improvement in arthritis, granulomatous dermatitis, and uveitis.
View Article and Find Full Text PDFEarly-Onset Generalized Pustular Psoriasis of Pregnancy Following Hydroxychloroquine Use.
Ann Dermatol
May 2023
Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea.
Generalized pustular psoriasis of pregnancy (GPPP), characterized by widespread sterile pustules and erythematous patches with systemic symptoms such as fever, is a rare form of pustular psoriasis. GPPP typically occurs in the third trimester of pregnancy and can be triggered by various factors such as infections, hypocalcemia, and drugs including -butyl-scopolammonium bromide. We report a rare case of new-onset GPPP in a 33-year-old multigravida female at 17 weeks' gestation, which occurred earlier than usual, after taking hydroxychloroquine for 3 weeks to treat systemic lupus erythematosus.
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