Background: The purpose of the present study was to investigate the antioxidant and antimicrobial activities of a conventional preservative system containing desferrioxamine mesylate (DFO) and optimize the composition of the system through mathematical models.
Methods: Different combinations of ethylenediaminetetraacetic acid (EDTA), sodium metabisulfite (SM), DFO and methylparaben (MP) were prepared using factorial design of experiments. The systems were added to ascorbic acid (AA) solution and the AA content over time, at room temperature and at 40 °C was determined by volumetric assay. The systems were also evaluated for antioxidant activity by a fluorescence-based assay. Antimicrobial activity was assessed by microdilution technique and photometric detection against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus brasiliensis. A multi-criteria decision approach was adopted to optimize all responses by desirability functions.
Results: DFO did not extend the stability of AA over time, but displayed a better ability than EDTA to block the pro-oxidant activity of iron. DFO had a positive interaction with MP in microbial growth inhibition. The mathematical models showed adequate capacity to predict the responses. Statistical optimization aiming to meet the quality specifications of the ascorbic acid solution indicated that the presence of DFO in the composition allows to decrease the concentrations of EDTA, SM and MP.
Conclusion: DFO was much more effective than EDTA in preventing iron-catalyzed oxidation. In addition, DFO improved the inhibitory response of most microorganisms tested. The Quality by Design concepts aided in predicting an optimized preservative system with reduced levels of conventional antioxidants and preservatives, suggesting DFO as a candidate for multifunctional excipient.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704847 | PMC |
| http://dx.doi.org/10.1007/s40199-020-00370-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dissecting the mechanisms of copper-azole wood preservatives detoxification by ligninolytic fungi.
J Hazard Mater
December 2024
Université de Lorraine, INRAE, IAM, Nancy F-54000, France. Electronic address:
Copper-azole based formulations have been widely used to protect wood timbers against fungal decay. While these treatments are efficient for wood protection, leaching of both copper and azoles into the environment has deleterious impact on soils and surface waters. No bioremediation process is currently available for disposable of these wood wastes.
View Article and Find Full Text PDFRecent progress in the source, extraction, activity mechanism and encapsulation of bioactive essential oils.
Crit Rev Food Sci Nutr
December 2024
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu, China.
There is growing concern about the potential risks posed by synthetic additives in industrial products, such as foods, cosmetics, agrochemicals, and personal care products. Many plant-derived essential oils (EOs) have been shown to exhibit excellent antibacterial, antifungal, antiviral, and antioxidant activities, and may therefore be used as natural preservatives in these applications. However, most EOs have relatively low water solubility and are prone to chemical degradation during storage.
View Article and Find Full Text PDFStable Pickering emulsions of cinnamaldehyde were formulated using tannic acid-assisted cellulose nanofibers and applied for mango preservation.
Int J Biol Macromol
December 2024
College of Food Science, Southwest University, Chongqing 400715, People's Republic of China; Research Center for Fruits and Vegetables Logistics Preservation and Nutritional Quality Control, Southwest University, Chongqing 400715, People's Republic of China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, People's Republic of China. Electronic address:
Recent explorations into cinnamaldehyde (CIN) have identified its potential as a natural preservative, particularly when incorporated into active packaging to enhance the shelf-life of fruits and vegetables. This study explores the use of cellulose nanofiber (CNF)-stabilized Pickering emulsions as a novel delivery system for essential oils, demonstrating broad applicability in food preservation strategies. We employ CNF as Pickering stabilizers to effectively emulsify and encapsulate CIN, investigating the influence of tannic acid (TA) concentrations on the stability of these emulsions.
View Article and Find Full Text PDFTowards responsible resource utilization: A review of sustainable vs. unsustainable reuse of wood waste.
PLoS One
December 2024
Department of Sociology and Social Work, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Abundant wood waste is generated globally, but the literature lacks a framework distinguishing sustainable versus unsustainable reuse practices. This gap hinders policy makers and stakeholders from effectively supporting responsible resource utilization. As such, this scoping review aimed to address this gap by evaluating wood waste reuse practices through ecological, financial, and social sustainability lenses.
View Article and Find Full Text PDFHydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling.
Int J Mol Sci
November 2024
College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China.
Acute liver injury (ALI) is an injury to liver tissue caused by viruses, drugs, alcohol, and oxygen deprivation, and is one of the most common and serious clinical disorders. Hydroxytyrosol (HT) is a naturally occurring polyphenolic compound isolated from forsythia and has excellent anti-inflammatory properties. However, the effect and mechanisms of HT in ALI remain unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!