Probiotic Bacteria can Modulate Murine Macrophage's Superoxide Production in Infection.

The effect of probiotic strains ( EF55, CCM7420, CCM8558, ED26E/7, CCM7421, 17L/1) on the production of superoxide anion (O ) in peritoneal macrophages of infected mice was examined. EF55 and CCM8558 strains increased the O production prior to parasitic infection,at the day7of application.A significant inhibition of the O production caused by infection on day 5 infection (p.i.) was prevented by all examined strains. Lactobacilli stimulated metabolic activity of macrophages during intestinal and early muscular phase (from day 5 to 25 p.i.) of trichinellosis. Enterococci increased the O production in early intestinal phase (day 5 p.i.) and during the muscular phase of trichinellosis (days 25 and 32 p.i.). Respected increase in macrophage's metabolic activity induced by probiotic treatment in the intestinal phase of trichinellosis augmented the host antiparasite defence (damage and killing of newborn larvae with reactive oxygen species from macrophages).