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Cerebellar stroke secondary to ovarian stimulation and patent foramen ovale.

Intern Med J

January 2025

Department of Neurology, St Vincent's Health Australia, Sydney, New South Wales, Australia.

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We report the case of a previously independent 82-year-old female who experienced acute hemodynamic and respiratory deterioration requiring inotropic support due to a fat embolism during revision hip arthroplasty. Computed tomography pulmonary angiography demonstrated fat embolism, and transesophageal echocardiogram showed evidence of right ventricle strain and fat embolism in-transit in the right heart, as well as a moderate patent foramen ovale. Under transesophageal echocardiogram and intravascular ultrasound guidance, the Inari FlowTriever thrombectomy device was used successfully to retrieve the fat embolism with immediate hemodynamic improvement, no complications, and uneventful recovery.

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[Secondary stroke prevention].

Radiologie (Heidelb)

January 2025

Klinik für Diagnostische und Interventionelle Neuroradiologie, Kirrberger Straße, Gebäude 90, 66421, Homburg/Saar, Deutschland.

Background: The treatment of strokes is based on two pillars: the efficient management of acute strokes to minimize permanent neurological deficits, and secondary prevention to avoid recurrence.

Objective: To summarize current recommendations for secondary stroke prevention.

Materials And Methods: Guidelines and recent studies on the most common causes of strokes, and their treatment and prevention are reviewed.

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This study aimed to investigate the metabolic mechanisms underlying the combination of patent foramen ovale (PFO) and migraine by assessing metabolite expression before and after interventional occlusion surgery. The study included 11 PFO patients from the Heart Center of Xinjiang Medical University Affiliated Hospital of Traditional Chinese Medicine, who underwent transcatheter PFO intervention and occlusion surgery between January 2018 and February 2023, and 11 healthy controls. Blood samples were collected pre-surgery, 3 days post-surgery, and 30 days post-surgery for metabolomics analysis.

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Article Synopsis
  • This study investigates how metabolic profiles change in patients with patent foramen ovale (PFO) and migraines before and after surgery, using metabolomics techniques.
  • Significant differences in metabolites like linoleic acid and quinolinic acid were observed after surgery, indicating potential diagnostic markers for these patients.
  • The research highlights the importance of metabolic pathways related to inflammation and oxidative stress in understanding migraines associated with PFO.
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