Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Driving Forces in the Formation of Biocondensates of Highly Charged Proteins: A Thermodynamic Analysis of the Binary Complex Formation.
Biomolecules
November 2024
Institut für Chemie und Biochemie, Freie Universität Berlin, Forschungsbau SupraFab, Altensteinstrasse 23a, 14195 Berlin, Germany.
A thermodynamic analysis of the binary complex formation of the highly positively charged linker histone H1 and the highly negatively charged chaperone prothymosin α (ProTα) is detailed. ProTα and H1 have large opposite net charges (-44 and +53, respectively) and form complexes at physiological salt concentrations with high affinities. The data obtained for the binary complex formation are analyzed by a thermodynamic model that is based on counterion condensation modulated by hydration effects.
View Article and Find Full Text PDFActivation of pro-resolving pathways mediate the therapeutic effects of thymosin beta-4 during -induced keratitis.
Front Immunol
October 2024
Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, United States.
Article Synopsis
- Current bacterial keratitis treatments inadequately address the inflammatory response that threatens vision; recent studies suggest thymosin beta-4 (Tβ4) enhances inflammatory resolution and bacterial killing.
- The study investigates how Tβ4 affects specialized pro-resolving lipid mediator (SPM) pathways, which are crucial for resolving inflammation, using a bacterial keratitis model and validating findings with specific cellular assays.
- Results show that Tβ4 significantly influences SPM enzymes and receptors, increases SPM production in the cornea, and enhances phagocytosis via SPM activation, supporting Tβ4's potential as a comprehensive treatment for bacterial keratitis.
Differences in alternative splicing events in the adaptive strategies of two Daphnia galeata genotypes induced by fish kairomones.
BMC Genomics
July 2024
Department of Biotechnology, Sangmyung University, Seoul, 03016, Korea.
Background: Daphnia galeata is a suitable model organism for investigating predator-induced defense. Genes and pathways exhibiting differential expression between fish kairomone-treated and untreated groups in D. galeata have been identified.
View Article and Find Full Text PDFSmall Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile.
Biomolecules
April 2024
Institute of Molecular Virology, Center for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms-University, Von-Esmarch-Str. 56, 48149 Muenster, Germany.
Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous research demonstrated the effectiveness of small spleen peptides (SSPs) in inhibiting psoriatic arthritis progression, even in the presence of the pro-inflammatory cytokine TNFα, by transforming dendritic cells (DCs) into tolerogenic cells and fostering regulatory Foxp3 Treg cells.
View Article and Find Full Text PDFComprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical Trials.
Altern Ther Health Med
January 2024
Objective: This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials. The focus was on Tα1's application in COVID-19, autoimmune conditions, and cancer treatment, with implications for future considerations.
Methods: We systematically searched articles relevant to critical studies on COVID-19, infectious diseases, cancer, and autoimmune diseases indexed on Pubmed, Google Scholar, and Cochrane Library.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!