The addition of lithium anion of (acetylmethylene)triphenylphosphorane to nonracemic sulfinimines was investigated. It was found that the addition proceeded with good diastereoselectivity and further reaction of the formed sulfinimidophosphorane with several aldehydes afforded the β-sulfinamido substituted enones in good yields. The resultant enones were elaborated to the synthesis of alkaloid (+)-241D, to the formal total synthesis of (+)-preussin, and to the synthesis of aminocyclopentenol.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.orglett.0c02608 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!