Implant based breast augmentation and reconstruction are highly prevalent surgeries performed worldwide. Despite the high level of safety associated with these surgeries, surgical intervention is often associated with post-operative complications, some of which have been directly related to the soft tissue biomechanics and the response to compression and loading forces exerted by the weight of the implant, and not necessarily its volume. Here we discuss the issue of weight, based upon the fundamental laws of physics, and present a solution with the development of a novel breast implant technology. The B-Lite® lightweight breast implant (G&G Biotechnology Ltd., Haifa, Israel) enables the surgeon to achieve the patient's desired breast size and shape while reducing both the risk of damage to the integrity and stability of the breast tissue as well as the risk of long-term breast tissue deformity. Such avoidance of tissue compromise and deformation as well as, ultimately, reoperation improves both patient safety and satisfaction. The lightweight implant, considered the world's first and only implant of its kind, represents a pioneering and meaningful innovation in plastic surgery, and may further improve the clinical outcomes of implant based breast augmentation and breast reconstruction. Disclosure: The authors are the sons of Dr. Jacky Govrin Yehudain, the inventor of the B-Lite® implant discussed in the article.
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Plast Surg (Oakv)
February 2025
Schulich School of Medicine, Western University, London, Canada.
Breast implants were first introduced in the 1960s and have long been used for augmentation and reconstructive breast surgery. More recently, fat grafting for breast augmentation has gained popularity due to the 'natural' outcome and lack of implant-related complications. The aim of this study was to conduct a systematic review and meta-analysis comparing patient-related outcome measures between fat grafting and implant-based primary augmentation using the validated BREAST-Q questionnaire.
View Article and Find Full Text PDFPlast Reconstr Surg
February 2025
From the Department of Plastic Surgery, Shanghai East Hospital, Tongji University School of Medicine.
Background: Cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer have been used to overcome the low survival rate of conventional lipotransfer. However, there is still insufficient evidence to determine which technique is the best strategy for autologous fat grafting in breast cosmetic and reconstructive surgery. The present study aimed to compare the efficacy of traditional fat transplantation, CAL, and PRP-assisted lipotransfer.
View Article and Find Full Text PDFMol Pharm
January 2025
State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
Natural killer (NK) cell immunotherapy is a significant category in tumor therapy due to its potent tumor-killing and immunomodulatory effects. This research delves into exploring the mechanisms underlying the ability of amoxicillin to boost NK cell cytotoxicity in NK cell immunotherapy. Amoxicillin significantly enhances the cytotoxic activity of NK-92MI cells against MCF-7 cells by triggering the initiation of a cytolytic program in target cell-deficient NK-92MI cells and augmenting the degranulation level of NK-92MI cells in the presence of target cells.
View Article and Find Full Text PDFAesthet Surg J
January 2025
Department of Plastic and Aesthetic Surgery, Sana Kliniken Duesseldorf GmBH, Graeulinger Strasse, Duesseldorf, Germany.
Background: Breasts with a broad base, constricted inframammary fold (IMF) and a short distance between the nipple and the IMF are predisposed to form a double bubble (DB) deformity. Most publications have focused on the correction of a DB rather than on its prevention and thorough analysis of the IMF.
Objectives: Introduction of a third dissection plane in breast augmentation for preventing or correcting DB deformities.
Front Immunol
January 2025
Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Introduction: Hyperthermia is an established adjunct in multimodal cancer treatments, with mechanisms including cell death, immune modulation, and vascular changes. Traditional hyperthermia applications are resource-intensive and often associated with patient morbidity, limiting their clinical accessibility. Gold nanorods (GNRs) offer a precise, minimally invasive alternative by leveraging near-infrared (NIR) light to deliver targeted hyperthermia therapy (THT).
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