AI Article Synopsis
- Endothelial-to-mesenchymal transition (EndMT) is a process where endothelial cells change into mesenchymal-like cells, losing their original characteristics, which can occur in various physiological or pathological situations.
- Recent studies highlight the significance of EndMT in the development of fibrotic cardiovascular diseases.
- The review covers the key pathways that induce EndMT and explores its role in these diseases, suggesting potential new therapeutic strategies.
Article Abstract
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.
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| http://dx.doi.org/10.1177/1074248420952233 | DOI Listing |
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