AI Article Synopsis
- This review examines recent findings on how immune checkpoint inhibitors (ICIs) can lead to unusual response patterns in cancer treatment, such as durable responses, pseudoprogression, and hyperprogression.
- It discusses the adaptations to the Response Evaluation Criteria in Solid Tumors (RECIST) to better evaluate responses to immunotherapy, although the standard RECIST1.1 is still predominantly used in trials.
- The article highlights that the effectiveness of continuing treatment after progression varies by cancer type and evaluation methods, with future studies needed to refine imaging techniques and biomarker use to predict who may benefit from ongoing treatment.
Article Abstract
Purpose Of Review: This review provides a comprehensive assessment of recent literature reports describing atypical response patterns observed with immune checkpoint inhibitors (ICIs), modifications to response evaluation criteria for ICIs, and treatment beyond progression in clinical trials.
Recent Findings: Certain response patterns such as durable response, pseudoprogression, hyperprogression, and dissociated responses can be seen with ICI treatment. These patterns carry differing prognoses and are associated with varied factors. There are multiple modifications of standard Response Evaluation Criteria in Solid Tumors (RECIST) that have been proposed to better characterize immunotherapy response; however, standard RECIST1.1 remains most commonly used in clinical trials. Treatment beyond progression varies in frequency and benefit depending on assessment criteria and cancer type. Future research incorporating modified imaging criteria and biomarker assessments may serve to clarify who will benefit most from treatment beyond progression.
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| http://dx.doi.org/10.1007/s11912-020-00974-z | DOI Listing |
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