The public health has declared an international state of emergency due to the spread of a new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential therapeutic agents is a dire need. To this aim, the SARS-CoV-2 spike (S) glycoprotein represents a crucial target for vaccines, therapeutic antibodies, and diagnostics. Since virus binding to ACE-2 alone could not be sufficient to justify such severe infection, in order to facilitate medical countermeasure development and to search for new targets, two further regions of S protein have been taken into consideration here. One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416604 | PMC |
| http://dx.doi.org/10.3389/fmolb.2020.00186 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice.
Colloids Surf B Biointerfaces
January 2025
Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, China.
Natural compounds have shown promising application prospects in preventing or treating various diseases, including osteoporosis on account of their abundant sources, low price, multi-targeting and multiple biological effects. As a bioactive natural product, quercetin (Que) has previously demonstrated to ameliorate osteoporosis (OP), however, its poor bioavailability resulting from low water solubility, poor stability and lack of bone-targeting largely restricted its efficacy and clinical applications. Inspired by the bone-targeting capability of phosphate compounds, we reported a one-step procedure for synthesis of phosphorylated Que (p-Que) by direct phosphorylating phenol groups of Que for the first time.
View Article and Find Full Text PDFObject detection in motion management scenarios based on deep learning.
PLoS One
January 2025
School of Physical Education, Jinjiang College, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
In athletes' competitions and daily training, in order to further strengthen the athletes' sports level, it is usually necessary to analyze the athletes' sports actions at a specific moment, in which it is especially important to quickly and accurately identify the categories and positions of the athletes, sports equipment, field boundaries and other targets in the sports scene. However, the existing detection methods failed to achieve better detection results, and the analysis found that the reasons for this phenomenon mainly lie in the loss of temporal information, multi-targeting, target overlap, and coupling of regression and classification tasks, which makes it more difficult for these network models to adapt to the detection task in this scenario. Based on this, we propose for the first time a supervised object detection method for scenarios in the field of motion management.
View Article and Find Full Text PDFSystematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma.
Br J Pharmacol
December 2024
Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Article Synopsis
- Cardiac glycosides (CGs), known for treating heart issues, also have potential as anticancer agents, particularly targeting specific tumors like uveal melanoma (UVM) through various mechanisms.
- The study created a workflow to discover effective CGs, analyzing their toxicity to cancer cells while mapping out involved genes and pathways.
- Results indicated that digitoxin significantly inhibits UVM cell growth and increases reactive oxygen species, making it a promising treatment option for UVM due to its ability to target more vulnerable malignant cells.
Identifying optimal tumor-associated antigen combinations with single-cell genomics to enable multi-targeting therapies.
Front Immunol
November 2024
Cartography Biosciences, South San Francisco, CA, United States.
Targeted antibody-based therapy for oncology represents a highly efficacious approach that has demonstrated robust responses against single tumor-associated antigen (TAA) targets. However, tumor heterogeneity presents a major obstacle for targeting most solid tumors due to a lack of single targets that possess the right on-tumor/off-tumor expression profile required for adequate therapeutic index. Multi-targeting antibodies that engage two TAAs simultaneously may address this challenge through Boolean logic-gating function by improving both therapeutic specificity and efficacy.
View Article and Find Full Text PDFComputer-Aided Identification and Design of Ligands for Multi-Targeting Inhibition of a Molecular Acute Myeloid Leukemia Network.
Cancers (Basel)
October 2024
Izmir Biomedicine and Genome Center, 35340 Balçova, İzmir, Türkiye.
Background/objectives: Acute myeloid leukemia (AML) is characterized by therapeutic failure and long-term risk for disease relapses. As several therapeutic targets participate in networks, they can rewire to eventually evade single-target drugs. Hence, multi-targeting approaches are considered on the expectation that interference with many different components could synergistically hinder activation of alternative pathways and demolish the network one-off, leading to complete disease remission.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!