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Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity. | LitMetric

Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity.

Front Cell Dev Biol

Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.

Published: July 2020

Homeotic genes are universal regulators of the body patterning process in embryogenesis of metazoans. The gene expression pattern ( code) retains in adult tissues and serves as a cellular positional identity marker. Despite previously existing notions that the code is inherent in all stroma mesenchymal cells as a whole, recent studies have shown that the code may be an attribute of a distinct subpopulation of adult resident mesenchymal stromal cells (MSC). Recent evidence allows suggesting a "non-canonical" role for gene expression which is associated with renewal and regeneration in postnatal organs after damage. In tissues with high regenerative capacity, it has been shown that a special cell population is critical for these processes, a distinctive feature of which is the persistent expression of tissue-specific genes. We believe that in the postnatal period Hox-positive subpopulation of resident MSC may serve as a unique regenerative reserve. These cells coordinate creation and maintenance of the correct structure of the stroma through a tissue-specific combination of mechanisms. In this article, we summarize data on the role of resident MSC with a tissue-specific pattern of gene expression as regulators of correct tissue reconstruction after injury.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412745PMC
http://dx.doi.org/10.3389/fcell.2020.00624DOI Listing

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