AI Article Synopsis
- Cartilage defects are a significant health issue for older adults due to cartilage's limited ability to heal itself, as it lacks blood vessels and nerves.
- Supramolecular hydrogels are being explored for cartilage regeneration because they are adaptable and can incorporate cells, making them promising for medical and tissue engineering applications.
- The review focuses on recent advancements in stem cell-laden supramolecular hydrogels, highlighting their potential in stem cell therapy for cartilage repair, while also addressing challenges and future directions in the field.
Article Abstract
Cartilage defects pose a great threat to the health of the aging population. Cartilage has limited self-regeneration ability because it lacks blood vessels, nerves and lymph. To achieve efficient cartilage regeneration, supramolecular hydrogels are used in medical applications and tissue engineering as they are tunable and reversible in nature. Moreover, they possess supramolecular interactions which allow the incorporation of cells. These hydrogels present great potential for tissue engineering-based therapies. This review presents advances in the development of stem cell-laden supramolecular hydrogels. We discuss new possibilities for stem cell therapy and their uses in cartilage tissue engineering. Gray areas and future perspectives are discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396708 | PMC |
| http://dx.doi.org/10.3389/fbioe.2020.00847 | DOI Listing |
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