Background And Aim: Although existing research confirms the antiparasitic effect of the Malacca plant against , its effect on the liver, one of the target organs of has not been investigated. Therefore, this study was conducted to explore the potential of the ethanolic extract of Malacca () leaves in preventing liver damage in mice () caused by infection.
Materials And Methods: This study was conducted using the livers of 18 mice fixed in 10% neutral-buffered formalin. A completely randomized design with a unidirectional pattern comprising six treatments was used in this study, with each treatment consisting of three replications. Treatment 0 was the negative control group infected with , treatment 1 was the positive control group infected with followed by chloroquine administration at a dose of 5 mg/kg BW, and treatments 2, 3, 4, and 5 were groups infected with and administered Malacca leaf ethanolic extracts at doses of 100, 300, 600, and 1200 mg/kg BW, respectively. The extracts were administered orally using a gastric tube for 4 consecutive days. Mice were sacrificed on the 7 day and livers were collected for histopathological examination.
Results: Histopathological examination of the livers of mice infected with demonstrated the presence of hemosiderin, hydropic degeneration, fat degeneration, necrosis, and megalocytosis. However, all these histopathological changes were reduced in the livers of -infected mice treated with various doses of Malacca leaf ethanolic extract. The differences between the treatments were found be statistically significant (p<0.05).
Conclusion: Ethanolic extract of Malacca leaves has the potential to protect against liver damage in mice infected with . The dose of 600 mg/kg BW was found to be the most effective compared with the doses of 100, 300, and 1200 mg/kg BW.
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http://dx.doi.org/10.14202/vetworld.2020.1457-1461 | DOI Listing |
Molecules
September 2022
Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
is an ancient remedy plant, known as the miraculous plant due to its many prominent uses and significant health benefits. It is a nutrient-rich plant, with exceptional bioactive compounds, such as polyphenols that possess several medicinal properties. Many significant studies have been carried out to evaluate the ethnomedicinal and pharmacological properties of in various applications.
View Article and Find Full Text PDFVet World
July 2020
Veterinary Education Study Program, Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh 23111, Indonesia.
Background And Aim: Although existing research confirms the antiparasitic effect of the Malacca plant against , its effect on the liver, one of the target organs of has not been investigated. Therefore, this study was conducted to explore the potential of the ethanolic extract of Malacca () leaves in preventing liver damage in mice () caused by infection.
Materials And Methods: This study was conducted using the livers of 18 mice fixed in 10% neutral-buffered formalin.
ScientificWorldJournal
December 2020
Pharmacology Laboratory, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
Malacca () is one of the plants that is often by the community in the Aceh Besar district of Indonesia as a traditional medicine for the treatment of various diseases such as antimicrobial, antibacterial, antifungals, antivirals, antimutagenic, antimalaria, and antiallergic. This research was conducted to analyze the content of chemical compounds in the ethanol extract of the Malacca leaf (EEDM) using a gas chromatography-mass spectrophotometer (GC-MS). Malacca leaves were extracted by the maceration method using n-hexane, ethyl acetate, and ethanol.
View Article and Find Full Text PDFSoutheast Asian J Trop Med Public Health
March 1981
Wild and domestic animals trapped from forests, villages, and rice fields in South Kalimantan (3 degrees 20' S, 115 degrees 02' E, 25 m) were examined for blood parasites using Giemsa stained thick and thin blood films and Nuclepore filter preparations of peripheral vein and heart puncture blood. Presbytis cristatus (silvered leaf monkey) (25%) and Felis catus (domestic cat) (7%) were infected with Brugia malayi and B. pahangi.
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