AI Article Synopsis
- Cytokines are proteins crucial for immune system regulation and are linked to various diseases, including rheumatoid arthritis, cancer, and COVID-19.
- Research is focusing on enhancing therapies and diagnostics through developing inhibitory drugs and biosensors for quick and effective detection.
- This paper analyzes IL-6 cytokine receptors using a theoretical approach to identify topological features, suggesting a new indicator for finding receptors that bind stably to proteins, and discusses their potential use in experiments.
Article Abstract
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557795 | PMC |
| http://dx.doi.org/10.3390/bios10090106 | DOI Listing |
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