Objective: To investigate the diagnostic values of serum presepsin, proadrenomedullin (proADM) and triggering receptor expressed on myeloid cells-1 (TREM-1) levels in children with acute pyelonephritis and lower urinary tract infection.
Methods: Peripheral venous blood and urine samples were obtained before starting antibiotic therapy at the time of admission in all patients. Serum TREM-1, presepsin and proADM concentrations were determined by the enzyme-linked immunosorbent assay method.
Results: 82 children (38 acute pyelonephritis, 24 lower urinary tract infection, 20 controls) were enrolled. Serum proADM and TREM-1 levels were higher in patients with acute pyelonephritis than those of lower urinary tract infection and controls (P=0.001 and P<0.001, respectively). Both serum proADM and TREM-1 levels had predictive value for diagnosis of acute pyelonephritis (P=0.006 and P<0.001, respectively). ROC analysis showed that proADM and TREM-1 had positive predictive values for diagnosis of acute pyelonephritis (AUC=0.830, P=0.003; and AUC=0.843, P<0.001, respectively).
Conclusions: Serum proADM and TREM-1 levels could serve as early biomarkers for the diagnosis of acute pyelonephritis in children.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Acute pyelonephritis in adults. Should we adopt the pediatric guidelines?
Urologia
December 2024
Department of Urology & Pediatric Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, Jerusalem, Israel.
Purpose: There are no guidelines, what recommend pro or against cystography for identification of VUR for adults who suffer from first episode of pyelonephritis. The aim of this study was to look at incidence of VUR in adults with first episode of pyelonephritis, and to highlight recommendations for possible reflux investigation in these patients.
Methods: We have performed retrospective review of all patients who admitted at our department over the last decade with the working diagnosis of acute pyelonephritis.
First case report of septic arthritis associated with an indwelling device.
Future Microbiol
December 2024
Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by and a literature review of invasive infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid.
View Article and Find Full Text PDFInitial experience of a novel ureteral silicon-covered metallic mesh stent in malignant ureteric obstruction: a single-center retrospective study.
BMC Urol
December 2024
Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
Background: This study aimed to investigate initial experiences and outcomes of a retrograde inserted new silicone-covered metallic ureteric stent (Urexel™) for malignant ureteric obstruction.
Methods: We retrospectively reviewed the medical records for 12 consecutive patients who underwent Urexel™ stent placement for malignant ureteric obstruction from March 2020 to March 2021. The Urexel™ stent is a segmental metallic ureteric stent composed of a nitinol mesh covered with a silicone membrane.
Acute Pyelonephritis Complicated With Spontaneous Subcapsular Renal Hematoma: A Case Report.
Cureus
November 2024
Internal Medicine, Centro Hospitalar de Trás-Os-Montes e Alto Douro, Vila Real, PRT.
Spontaneous subcapsular renal hematoma is a rare condition defined as spontaneous hemorrhage confined to the subcapsular and/or perirenal space. Its etiology can vary, ranging from renal tumors to vascular diseases, renal cysts, or infections. Here, we report the case of a 54-year-old male who presented to the emergency department with a two-day history of abdominal pain and fever.
View Article and Find Full Text PDFDrug Reaction With Eosinophilia and Systemic Symptoms Secondary to Trimethoprim/Sulfamethoxazole: A Case Report.
Cureus
November 2024
Emergency Medicine, Memorial Healthcare System, Hollywood, USA.
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a rare and potentially life-threatening condition. Symptoms typically manifest two to eight weeks after exposure to an offending agent, such as anticonvulsants and antibiotics. Clinical features include fever, morbilliform rash, eosinophilia, lymphadenopathy, and, in severe cases, multiorgan dysfunction, including interstitial nephritis, hepatitis, and pneumonitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!