[The analysis of association between multiple sclerosis and genetic markers identified in genome-wide association studies].

Objective: Our aim was to analyse the association with multiple sclerosis of the genetic markers of autoimmune disorders identified in genome-wide association studies in ethnically homogenous groups of Russians and Tatars residing in the Republic of Bashkortostan.

Material And Methods: We performed genotyping of the genetic variants rs2069762 in gene, rs759648 in gene, rs1800682 in gene and rs12708716 in gene in the study group consisting of 1724 people (547 patients with multiple sclerosis, 1177 representatives of the control group). We analysed the association of the studied genetic markers with multiple sclerosis using logistic regression under additive genetic model implemented in PLINK program with sex a covariate.

Results: In the group of Tatars, we detected an association of rs759648*Callele with multiple sclerosis (OR=1.42, =0,023). Meta-analysis of the study results in the two ethnic groups we confirmed the association of the rs759648*C allele with the disease (random effects model and fixed effect model: OR=1.29, =0,018).

Conclusion: Our results provide an evidence of an association between multiple sclerosis and the rs759648 allele in the populations of Russian and Tatars from the Republic of Bashkortostan. No association with any other studied polymorphic variant was found in the two ethnic groups.