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Endometrial miRNome profile according to the receptivity status and implantation failure. | LitMetric

Endometrial miRNome profile according to the receptivity status and implantation failure.

Hum Fertil (Camb)

Univ Montpellier, INSERM U1203, EmbryoPluripotency, Montpellier, France.

Published: April 2022

AI Article Synopsis

  • - The study analyzes the miRNome (microRNA profile) of endometrial samples during the implantation window to see if it can predict outcomes in Assisted Reproduction Technology (ART) for patients with repeated implantation failures (RIF).
  • - It involves a discovery cohort of 20 patients to identify various miRNAs associated with receptivity and outcomes like early miscarriage or live birth, followed by a validation cohort of 103 RIF patients to confirm findings with RT-qPCR.
  • - Ultimately, four specific miRNAs are significantly linked to endometrial receptivity and implantation failure, suggesting that analyzing these profiles could help predict pregnancy success and enhance ART effectiveness.

Article Abstract

This is a retrospective study to evaluate if the miRNome profile of endometrium samples collected during the implantation window predicts Assisted Reproduction Technology (ART) outcomes. We first investigated the endometrial miRNome profile according to the receptivity status in 20 patients with repeated implantation failures (RIF) (discovery cohort). After customized embryo transfer, the miRNome profiles of receptive patients with a positive or negative β-hCG, and with early miscarriage or live birth were analysed. Some differentially expressed miRNAs were selected for validation by RT-qPCR in endometrial samples from 103 RIF patients (validation cohort). Analysis of the different miRNome profiles identified endometrial receptivity, implantation failure, and early miscarriage-associated miRNA signatures that included 11, 261, and 76 miRNAs, respectively. However, only four miRNAs associated with the endometrial receptivity status (miR-455-3p and miR-4423-3p) and implantation failure (miR-152-3p and miR-155-5p) were significantly validated in endometrial samples. The miRNome profile of endometrial tissues during the implantation window can predict the pregnancy outcome. These data are crucial for opening new perspectives to predict implantation failure and consequently, to increase ART success.

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Source
http://dx.doi.org/10.1080/14647273.2020.1807065DOI Listing

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