A performance assessment of two different indices (the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI)) for monitoring short-term and short-medium-term drought impacts on daily specific-cause mortality in Spain was conducted. To achieve a comprehensive, nationwide view, a meta-analysis was performed using a combination of provincial relative risks (RRs). Moreover, the subdivisions of Spain based on administrative, climatic, and demographic criteria to obtain the measures of combined risks were also taken into account. The results of the SPEI and SPI calculated at the same timescale were similar. Both showed that longer drought events produced greater RR values, for respiratory mortality. However, at the local administrative level, Galicia, Castilla-y-Leon, and Extremadura showed the greatest risk of daily mortality associated with drought episodes, with Andalucía, País Vasco, and other communities being notably impacted. Based on climatic regionalization, Northwest, Central, and Southern Spain were the regions most affected by different drought conditions for all analyzed causes of daily mortality, while the Mediterranean coastal region was less affected. Demographically, the regions with the highest proportion of people aged 65 years of age and over reflected the greatest risk of daily natural, circulatory, and respiratory mortality associated with drought episodes.
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http://dx.doi.org/10.3390/ijerph17176114 | DOI Listing |
Porcine Health Manag
December 2024
Pig Development Department, Animal and Grassland Research and Innovation Centre, Teagasc Moorepark, P61C996, Fermoy, Co. Cork, Ireland.
Background: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
View Article and Find Full Text PDFBMC Urol
December 2024
Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Background: Immune checkpoint inhibitors (ICIs) alone or in combination with standard chemotherapy for advanced urothelial carcinoma (UC) have been tested as first-line treatment in clinical trials. This study aimed to evaluate the clinical outcomes of programmed cell death 1 (PD-1) inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic UC in a real world clinical care setting, and sought to identify prognostic factors for overall survival (OS).
Methods: A retrospective, real-world study involving 35 locally advanced or metastatic UC patients treated with PD-1 inhibitor alone or in combination with chemotherapy was conducted.
Anticancer Res
January 2025
Department of Thoracic Oncology, Osaka Habikino Medical Center, Osaka, Japan.
Background/aim: The clinical benefits of durvalumab consolidation therapy following concurrent chemoradiotherapy (CCRT) with daily low-dose carboplatin in elderly patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) remain unclear.
Patients And Methods: This was a single-institution retrospective cohort study. We analyzed the medical records of consecutive patients diagnosed with NSCLC who received CCRT with daily low-dose carboplatin from April 2014 to March 2021.
J Aquat Anim Health
December 2024
Virginia Institute of Marine Science, William & Mary, Gloucester Point, Virginia, USA.
Objective: The dinoflagellate Alexandrium monilatum forms blooms during summer in tributaries of the lower Chesapeake Bay. Questions persist about the potential for A. monilatum to negatively affect aquatic organisms.
View Article and Find Full Text PDFSci Rep
December 2024
MARE - Marine and Environment Sciences Centre/ARNET - Aquatic Research Network, Ispa - Instituto Universitário, Lisboa, Portugal.
While numerous studies have established correlations between parasite load and negative effects on their hosts, establishing causality is more challenging because parasites can directly compromise host condition and survival or simply opportunistically thrive on an already weakened host. Here, we evaluated whether Ixodes uriae, a widespread seabird tick, can cause a decrease in growth parameters (body mass, bill length and growth rates) and survival of chicks of a colonially seabird, the black-browed albatross (Thalassarche melanophris) breeding on New Island (West Falkland). To investigate this, we daily removed the ticks from 28 randomly selected chicks during their first 14 days of life (treated chicks) and compared their growth and survival with 49 chicks of a control group.
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