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Current approaches in CRISPR-Cas systems for diabetes.
Prog Mol Biol Transl Sci
January 2025
R and D, Salem Microbes Private Limited, Salem, Tamil Nadu, India. Electronic address:
In the face of advancements in health care and a shift towards healthy lifestyle, diabetes mellitus (DM) still presents as a global health challenge. This chapter explores recent advancements in the areas of genetic and molecular underpinnings of DM, addressing the revolutionary potential of CRISPR-based genome editing technologies. We delve into the multifaceted relationship between genes and molecular pathways contributing to both type1 and type 2 diabetes.
View Article and Find Full Text PDF4D flow cardiac magnetic resonance in pediatric congenital heart disease: Insights from over four years of clinical practice.
Clin Imaging
January 2025
Institute of Clinical sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Dept of Pediatric Radiology, The Queen Silvia Children's Hospital, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Background: Congenital heart diseases (CHDs) are common birth defects. This work presents over four years of clinical experience of 4D flow cardiovascular magnetic resonance (CMR), highlighting its value for pediatric CHD.
Methods: Children with various CHD diagnoses (n = 298) were examined on a 1.
An applied noise model for low-loss EELS maps.
Ultramicroscopy
January 2025
Nanopatterning-Nanoanalysis-Photonic Materials Group, Department of Physics, Paderborn University, Warburgerstr. 100, Paderborn, 33098, Germany. Electronic address:
Electron energy-loss spectroscopy (EELS) performed in a scanning transmission electron microscope (STEM) is susceptible to noise, just like every other measurement. EELS measurements are also affected by signal blurring, related to the energy distribution of the electron beam and the detector point spread function (PSF). Moreover, the signal blurring caused by the detector introduces correlation effects, which smooth the noise.
View Article and Find Full Text PDFAssessing the impact of messages about reduced nicotine cigar products among people who use little cigar and cigarillo: Insights from a discrete choice experiment.
Nicotine Tob Res
January 2025
Department of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Introduction: The U.S. Food and Drug Administration's (FDA) pursuit of a low nicotine standard for cigarettes raises concerns that a focus on cigarettes may encourage people to use other combusted tobacco products, undermining the policy's effectiveness.
View Article and Find Full Text PDFIsolated right superior vena cava drainage into the left atrium.
Indian J Thorac Cardiovasc Surg
February 2025
Dept of CTVS, NEIGRIHMS, Shillong, India.
Isolated right superior vena cava (RSVC) drainage into the left atrium (LA) is a rare congenital anomaly, presenting diagnostic and management challenges. This study presents two cases of isolated RSVC drainage into the LA alongside a comprehensive literature review to improve understanding and delineate optimal surgical approaches. The study describes two cases of isolated RSVC drainage into the LA and their surgical management.
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