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Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Published: December 2020
AI Article Synopsis
Scientists are studying a type of fungus called Candida auris, which can make people sick, to understand how our immune system reacts to it.
They found out that C. auris triggers a strong response in immune cells but doesn't get destroyed as easily by special immune fighters called macrophages.
In tests on animals, C. auris turned out to be less harmful compared to C. albicans, another type of fungus, showing that it could be a strong activator of our immune defense.
Article Abstract
Candida auris is among the most important emerging fungal pathogens, yet mechanistic insights into its immune recognition and control are lacking. Here, we integrate transcriptional and functional immune-cell profiling to uncover innate defence mechanisms against C. auris. C. auris induces a specific transcriptome in human mononuclear cells, a stronger cytokine response compared with Candida albicans, but a lower macrophage lysis capacity. C. auris-induced innate immune activation is mediated through the recognition of C-type lectin receptors, mainly elicited by structurally unique C. auris mannoproteins. In in vivo experimental models of disseminated candidiasis, C. auris was less virulent than C. albicans. Collectively, these results demonstrate that C. auris is a strong inducer of innate host defence, and identify possible targets for adjuvant immunotherapy.
