The aim of this study was to review the literature regarding the external contamination of commercial vials by antineoplastic drugs. A PubMed and CINAHL searches from 1 January 1990 to 1 May 2018 was performed with the terms: « antineoplastic agents », « environmental monitoring », « drug packaging », « vials » and « contamination ». Articles that presented results on the external contamination of commercial vials were included. Twenty-four articles were identified from 11 countries. A total of 4248 vials were sampled from 28 manufacturers. Traces were found on 56% (2379/4248) of vials. A maximum of 150 000 ng was measured on a glass vial of fluorouracil. This literature review showed that the exterior of the majority of commercial antineoplastic vials was contaminated. Manufacturers should limit this contamination. Centres are also encouraged to clean the vials on receipt. Personal protection equipment should be worn at all steps of the drug-use process.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447249 | PMC |
| http://dx.doi.org/10.1136/ejhpharm-2018-001705 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microaerobic biodegradation of aromatic hydrocarbon mixtures: strategies for efficient nitrate and oxygen dosage.
Appl Microbiol Biotechnol
January 2025
Department of Environmental Technology, Wageningen University & Research, P.O. Box 17, 6700 AA, Wageningen, The Netherlands.
The biodegradation of organic aromatic compounds in subsurface environments is often hindered by limited dissolved oxygen. While oxygen supplementation can enhance in situ biodegradation, it poses financial and technical challenges. This study explores introducing low-oxygen concentrations in anaerobic environments for efficient contaminant removal, particularly in scenarios where coexisting pollutants are present.
View Article and Find Full Text PDFDirect electrochemical sensing of ampicillin in aqueous media by a ruthenium oxide electrode decorated with a molecularly imprinted polymer.
Talanta
January 2025
Department of Materials and Environmental Technology, Tallinn University of Technology, Ehitajate tee 5, 19086, Tallinn, Estonia. Electronic address:
Ampicillin (AMP) ranks third among the top ten most frequently sold antibiotic combinations globally, raising concerns due to its extensive use. Improper disposal practices in agriculture, aquaculture, and healthcare have led to environmental contamination of water sources with elevated AMP levels. Current methods for detecting such contamination are costly, require sophisticated equipment, and depend on skilled personnel and unstable natural receptors.
View Article and Find Full Text PDFSpatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater.
ACS ES T Water
January 2025
Department of Statistics & Data Science, Dietrich College of Humanities and Social Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Since the start of the coronavirus-19 pandemic, the use of wastewater-based epidemiology (WBE) for disease surveillance has increased throughout the world. Because wastewater measurements are affected by external factors, processing WBE data typically includes a normalization step in order to adjust wastewater measurements (e.g.
View Article and Find Full Text PDFModeling the impact of extreme weather events and future climate on the radiologically contaminated sites of Enewetak Atoll.
Sci Rep
January 2025
Pacific Northwest National Laboratory, Richland, WA, USA.
Enewetak Atoll underwent 43 historical nuclear tests from 1948 to 1958, including the first hydrogen bomb test, resulting in a substantial nuclear material fallout contaminating the Atoll and the lagoon waters. The radionuclide fallout material deposited in lagoon sediments and soil on the islands will remain for decades to come. With intensifying climate and extreme weather events, the possibility of redistribution of deposited radionuclide material has become a great concern.
View Article and Find Full Text PDFDeveloping predictive models for assessing LC of organic contaminants in Gammarus species using interpretable structural parameters.
Aquat Toxicol
January 2025
Department of Chemistry, Semnan University, Iran.
Gammarus species are crucial indicators of environmental health, making them important for ecological studies and water quality assessments. They offer a wide range of specific responses regarding the median lethal concentration (LC) of organic compounds. This research presents four predictive models to determine the LC of chemicals impacting selected gammarid amphipods: Gammarus lacustris, Gammarus fasciatus, Gammarus pulex, and Gammarus pseudolimnaeus.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!