Protective Effects of CVD and DM Medications in SARS-CoV-2 Infection.

SN Compr Clin Med

School of Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Published: August 2020

Despite the burden of disease of CVD and DM, there is a lack of experimentally validated literature exploring their association with exacerbation of COVID-19. Target receptors of medications commonly used to treat CVD and DM may be involved in the viral entry mechanism of SARS-CoV-2. We propose the potential protective effects of these medications in COVID-19 infections, highlighting the need for further research. Firstly, AMPK mediated phosphorylation of ACE-2 by metformin as well as the drug's alkaline properties may interrupt the natural disease progression. Secondly, DPP4 receptor involvement in the putative viral entry of SARS-CoV-2 may be prevented by DPP4i. Finally, recent studies have shown that statins' ability to inhibit the cytokine storm may outweigh concerns of statin mediated ACE-2 upregulation in COVID-19. The complex interplay of factors affecting CVD and DM in COVID-19 patients makes the direct effects of medications difficult to examine. Therefore, further research is needed, in the context of SARS-CoV-2 and the molecular pathways it exploits, to potentially repurpose such pre-existing drugs for their use in COVID-19.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431108PMC
http://dx.doi.org/10.1007/s42399-020-00452-4DOI Listing

Publication Analysis

Top Keywords

protective effects
8
viral entry
8
effects medications
8
covid-19
5
cvd
4
effects cvd
4
medications
4
cvd medications
4
sars-cov-2
4
medications sars-cov-2
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!