Dynamics and control of COVID-19 pandemic with nonlinear incidence rates.

Nonlinear Dyn

Department of Engineering Design, IIT Madras, Chennai, 600036 India.

Published: June 2020

World Health Organization (WHO) has declared COVID-19 a pandemic on March 11, 2020. As of May 23, 2020, according to WHO, there are 213 countries, areas or territories with COVID-19 positive cases. To effectively address this situation, it is imperative to have a clear understanding of the COVID-19 transmission dynamics and to concoct efficient control measures to mitigate/contain the spread. In this work, the COVID-19 dynamics is modelled using susceptible-exposed-infectious-removed model with a nonlinear incidence rate. In order to control the transmission, the coefficient of nonlinear incidence function is adopted as the Governmental control input. To adequately understand the COVID-19 dynamics, bifurcation analysis is performed and the effect of varying reproduction number on the COVID-19 transmission is studied. The inadequacy of an open-loop approach in controlling the disease spread is validated via numerical simulations and a robust closed-loop control methodology using sliding mode control is also presented. The proposed SMC strategy could bring the basic reproduction number closer to 1 from an initial value of 2.5, thus limiting the exposed and infected individuals to a controllable threshold value. The model and the proposed control strategy are then compared with real-time data in order to verify its efficacy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315126PMC
http://dx.doi.org/10.1007/s11071-020-05774-5DOI Listing

Publication Analysis

Top Keywords

nonlinear incidence
12
covid-19 pandemic
8
covid-19 transmission
8
covid-19 dynamics
8
reproduction number
8
covid-19
7
control
6
dynamics
4
dynamics control
4
control covid-19
4

Similar Publications

Importance: Climate change can adversely affect mental health, but the association of ambient temperature with psychiatric symptoms remains poorly understood.

Objective: To assess the association of ambient temperature exposure with internalizing, externalizing, and attention problems in adolescents from 2 population-based birth cohorts in Europe.

Design, Setting, And Participants: This cohort study analyzed data from the Dutch Generation R Study and the Spanish INMA (Infancia y Medio Ambiente) Project.

View Article and Find Full Text PDF

Aim: Previous research has shown a strong association between insulin resistance (IR) and both the onset and advancement of diabetic kidney disease (DKD). This research focuses on examining the relationship between IR and all-cause mortality in individuals with DKD.

Methods: This study utilized data obtained from the National Health and Nutrition Examination Survey (NHANES), spanning the years 2001 to 2018.

View Article and Find Full Text PDF

Background: The triglyceride-glucose (TyG) index has been identified as an alternative biomarker for insulin resistance (IR), while residual cholesterol (RC) is a simple, cost-effective, and easily detectable lipid metabolite. However, the associations of these two markers with carotid plaque presence remain unclear. Thus, this study aimed to explore their associations with carotid plaque presence.

View Article and Find Full Text PDF

Objectives: The obesity paradox is common among older adults at risk for various diseases. Although this paradox has also been observed in the association between obesity and osteoporosis, the available evidence remains controversial. This study aimed to investigate the association between obesity and OP risk in an older population.

View Article and Find Full Text PDF

The literature has documented conflicting and inconsistent associations between muscle-to-fat ratios and metabolic diseases. Additionally, different adipose tissues can have contrasting effects, with visceral adipose tissue being identified as particularly harmful. This study aimed to explore the relationship between the ratio of the lean mass index (LMI) to the visceral fat mass index (VFMI) and cardiometabolic disorders, including dyslipidemia, hypertension, and diabetes, as previous research on this topic is lacking.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!