AI Article Synopsis
- The study aimed to analyze outcomes for LR-3 and LR-4 lesions without arterial phase hyperenhancement (APHE) and identify features predicting progression to LR-5 using Gd-EOB-DTPA-enhanced MRI.
- The research included 49 cirrhotic patients with a total of 55 LR-3 and 19 LR-4 lesions, focusing on changes in observation categories during follow-up based on size and specific LI-RADS features.
- Results showed that a diameter of 10 mm or greater significantly increased the risk of progression to LR-5 for both LR-3 and LR-4 lesions, with many observations remaining stable or downgraded during follow-up.
Article Abstract
Objective: The aim of this study was to retrospectively analyze the outcome of LR-3 and LR-4 without arterial phase hyperenhancement (APHE), and identify which features could predict LR-5 progression on serial Gd-EOB-DTPA-enhanced MRI follow-up.
Methods: Forty-nine cirrhotic patients with 55 LR-3 and 19 LR-4 without APHE were evaluated. Observations were classified as decreased, stable or increased in category at follow-up. Observation size and LI-RADS major and ancillary features were evaluated.
Results: Seventeen/fifty-five (31%) LR-3 and 8/19 (42%) LR-4 progressed to LR-5 at follow-up. Baseline LI-RADS major and ancillary features were not significantly different among LR-3 and LR-4. A diameter ≥ 10 mm significantly increased LR-5 progression risk of LR-3 (OR = 6.07; 95% CI: 0.12; 60.28]; P < .001). LR-4 with a diameter ≥ 10 mm more likely become LR-5 at follow-up (OR = 8.95; 95% CI: 0.73; 111.8; P = .083]).
Conclusion: LR-3 and LR-4 without APHE were often downgraded or remained stable in category on Gd-EOB-DTPA-enhanced MRI follow-up.
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| http://dx.doi.org/10.1016/j.clinimag.2020.08.003 | DOI Listing |
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