An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a AgCO/Sphos-mediated HIE protocol with DO as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.
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Org Biomol Chem
September 2020
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing Tech. University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P. R. China.
An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a AgCO/Sphos-mediated HIE protocol with DO as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.
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