Purpose: Compare depth-resolved biomechanical properties in normal and keratoconic corneas in live human subjects using optical coherence elastography (OCE).
Methods: In a prospective series of normal and keratoconus (KC) eyes, a corneal perturbation was applied by a custom swept-source OCE system using a transparent flat lens coupled to force transducers. Cross-correlation was applied to track frame-by-frame OCT speckle displacement. Regional displacements for the anterior and posterior stroma were plotted in force versus displacement () graphs. A spatial biomechanical property ratio ( ) was defined by dividing the maximum total displacement by the maximum force for the anterior ( ) and posterior cornea ( and was compared between normal and KC groups with the Mann-Whitney test. Area under the receiver operating characteristics curve (AUROC) for differentiating normal and KC eyes was calculated for , k, and thinnest point of corneal thickness (TPCT).
Results: Thirty-six eyes were analyzed (21 eyes of 12 normal subjects and 15 KC eyes of 12 subjects). The for the normal group was 1.135 ± 0.07 (mean ± standard deviation) and 1.02 ± 0.08 for the KC group ( < 0.001), indicating a relative deficit in anterior stromal stiffness in KC eyes. AUROC was 0.91 for / , 0.95 for k, and 1 for TPCT.
Conclusions: Significant differences in depth-dependent corneal biomechanical properties were observed between normal and KC subjects.
Translational Relevance: OCE was applied for the first time to human KC subjects and revealed alterations in the normal anterior-to-posterior stromal stiffness gradient, a novel and clinically accessible disease biomarker.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414661 | PMC |
| http://dx.doi.org/10.1167/tvst.9.7.4 | DOI Listing |
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