ACE2 enhance viral infection or viral infection aggravate the underlying diseases.

Comput Struct Biotechnol J

Howard University College of Medicine, 520 W Street NW, Washington, DC 20059 USA.

Published: August 2020

AI Article Synopsis

Article Abstract

ACE2 plays a critical role in SARS-CoV-2 infection to cause COVID-19 and SARS-CoV-2 spike protein binds to ACE2 and probably functionally inhibits ACE2 to aggravate the underlying diseases of COVID-19. The important factors that affect the severity and fatality of COVID-19 include patients' underlying diseases and ages. Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409731PMC
http://dx.doi.org/10.1016/j.csbj.2020.08.002DOI Listing

Publication Analysis

Top Keywords

underlying diseases
16
viral infection
8
aggravate underlying
8
ace2
4
ace2 enhance
4
enhance viral
4
infection viral
4
infection aggravate
4
underlying
4
diseases
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!