ACE2 plays a critical role in SARS-CoV-2 infection to cause COVID-19 and SARS-CoV-2 spike protein binds to ACE2 and probably functionally inhibits ACE2 to aggravate the underlying diseases of COVID-19. The important factors that affect the severity and fatality of COVID-19 include patients' underlying diseases and ages. Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409731 | PMC |
http://dx.doi.org/10.1016/j.csbj.2020.08.002 | DOI Listing |
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