We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500950 | PMC |
| http://dx.doi.org/10.7554/eLife.58042 | DOI Listing |
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