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Systemic sclerosis-related fecal incontinence: a scoping review focusing on a neglected manifestation.
Rheumatology (Oxford)
December 2024
Johns Hopkins University, Baltimore, Maryland.
Objectives: This scoping-review sought to summarize the current knowledge on the epidemiology, pathogenesis, clinical presentation, and the investigations that may help characterize faecal incontinence (FI) in patients with systemic sclerosis (SSc).
Methods: The planned scoping review was based on the methodological framework proposed by Arksey & O'Malley.Two databases were screened: PubMed (Medline), (webofSciences), data extraction was performed using a predefined template.
Clustering regional patterns of left ventricular longitudinal strain in systemic sclerosis-related pulmonary hypertension.
Int J Cardiol
December 2024
The Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Systemic sclerosis-related pulmonary hypertension (SSc-PH) is a heterogeneous disease, often complicated by concomitant left ventricular (LV) dysfunction. However, the contribution of heterogeneity in LV dysfunction is unclear. The objective in this study was to identify regional clusters of LV longitudinal strain via echocardiography to determine how subgroups of LV dysfunction contribute to mortality in SSc-PH.
View Article and Find Full Text PDFComparing three-dimensional zero echo time (3D-ZTE) lung MRI and chest CT in the evaluation of systemic sclerosis-related interstitial lung disease.
Eur Radiol
November 2024
Department of Rheumatology, Pamukkale University School of Medicine, Denizli, Turkey.
Objective: Systemic sclerosis (SSc) is a chronic disease that can cause interstitial lung disease (ILD), a poor prognostic factor in SSc patients. Given the concerns over radiation exposure from repeated CT scans, there is a growing interest in exploring radiation-free imaging alternatives like MRI for ILD evaluation. The aim of this study is to assess the efficacy of three-dimensional zero echo time (3D-ZTE) MRI in assessing SSc-related ILD compared to the thin-slice chest CT.
View Article and Find Full Text PDFExpanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing.
J Autoimmun
December 2024
Systemic Autoimmune Diseases Unit, Internal Medicine Department, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Systemic Autoimmune Diseases Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Article Synopsis
- The study focused on creating a new test to detect specific autoantibodies in patients with systemic sclerosis (SSc) using RNA immunoprecipitation and massive parallel sequencing techniques.
- Researchers analyzed serum samples from 307 SSc patients, with 57 undergoing detailed testing that identified 30,966 RNA molecules, ultimately narrowing down to 197 significant molecules linked to SSc-related autoantibodies.
- The new assay demonstrated high sensitivity and specificity in detecting autoantibodies, revealing not only known targets but also potential new ones associated with different clinical aspects of SSc.
Usefulness of monitoring mycophenolic acid exposure in systemic sclerosis-related interstitial lung disease: a retrospective cohort study.
BMC Pulm Med
October 2024
Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, North Hospital, Marseille, France.
Background: Systemic sclerosis-related interstitial lung disease (SSc-ILD) represents a significant cause of morbidity and mortality in Systemic Sclerosis (SSc). Mycophenolate mofetil (MMF) is currently the first line treatment for SSc-ILD. There is no recommendation on the dosage of mycophenolic acid (MPA) blood concentrations, so we aimed to study the correlation between MPA exposure and respiratory outcomes in this population.
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