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The causal association between cardiovascular proteins and diabetic nephropathy: a Mendelian randomization study.
Int Urol Nephrol
January 2025
Department of Nephrology, Jiangxi Medical College, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Purpose: To clarify the causal association between cardiovascular proteins and diabetic nephropathy (DN) in Europeans.
Methods: The large genome-wide association study data of cardiovascular proteins and DN were used for this two-sample Mendelian randomization (MR) analysis. We took the Inverse variance weighted (IVW) as the primary method.
Regeneration of Vascular Endothelium in Different Large Vessels.
Int J Mol Sci
January 2025
Department of Cell Biology, IFOM ETS-The AIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milan, Italy.
The regeneration of endothelial cells (ECs) lining arteries, veins, and large lymphatic vessels plays an important role in vascular pathology. To understand the mechanisms of atherogenesis, it is important to determine what happens during endothelial regeneration. A comparison of these processes in the above-mentioned vessels reveals both similarities and some significant differences.
View Article and Find Full Text PDFHemorrhagic Stroke in a 24-Year-Old Male With Polycythemia Vera: A Case Report and Literature Review.
Cureus
December 2024
Neurology, St. Luke's Medical Center, Quezon City, PHL.
Stroke is the second leading cause of death worldwide, according to the latest report by the World Health Organization (WHO). Intracerebral hemorrhage comprises 20-25% of the stroke in the young, with incidence rates of three to six in 100,000 people per year. One of the most common and important causes of hemorrhagic stroke in the general population is hypertension.
View Article and Find Full Text PDFClinical, antibiotic resistance features, and treatment outcomes of Vietnamese patients with community-acquired sepsis caused by .
IJID Reg
March 2025
Micobiology and Moclecular Biology Department, National Hospital for Tropical Diseases, Hanoi, Vietnam.
Objectives: This study describes the clinical and paraclinical features, antibiotic resistance levels, and treatment outcomes of septicemia acquired in the Vietnamese community.
Methods: A cross-sectional descriptive study was conducted on 102 patients with community-acquired sepsis caused by from July 2018 to July 2023.
Results: -induced community sepsis had a septic shock rate of 13.
Endoplasmic reticulum stress-MMRN1 positive feedback contributes to cisplatin resistance in small cell lung cancer.
J Thorac Dis
December 2024
Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Background: Small cell lung cancer (SCLC) accounts for 15% of all lung cancers and presents early metastasis and poor prognosis. Chemotherapy with cisplatin (CDDP) remains one of the standards of care in first-line treatment. However, the emergence of acquired resistance to CDDP causes disease progression and cancer recurrence.
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