[Place and modalities of postoperative radiotherapy in the management of cerebral metastases].

Cancer Radiother

Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France; Centre de recherche en informatique, signal et automatique de Lille, CRIStAL UMR 9189, université de Lille, bâtiment Esprit, avenue Henri-Poincaré, 59655 Villeneuve-d'Ascq, France.

Published: October 2020

AI Article Synopsis

Article Abstract

Metastases are the most common brain tumors. After surgery, stereotactic radiotherapy (SRT) of the resection cavity is the standard of care. Data from two randomized trials indicate that SRT to the surgical bed is an effective treatment in reducing local failure as compared with observation, while reducing the risk of cognitive deterioration and maintaining quality of life as compared with whole brain radiation therapy. Local control appears higher after hypofractionated SRT compared to single-fraction SRT. Several questions such as target volumes, the optimal regimen in particular for large tumor bed, strategies to reduce the risk of lepto-meningeal recurrence, and the treatment sequence still need to be answered.

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Source
http://dx.doi.org/10.1016/j.canrad.2020.06.019DOI Listing

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