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Rapid and Non-Targeted Qualitative and Quantitative Detection of miRNA in Complex Biological Samples Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with a 3-Aminoquinoline and 2',4',6'-Trihydroxyacetophenone Ionic Liquid Matrix.
J Am Soc Mass Spectrom
January 2025
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China.
A novel ionic liquid MALDI matrix, 3-aminoquinoline/2',4',6'-trihydroxyacetophenone monohydrate (3-AQ/THAP), was developed for the rapid qualitative and quantitative detection of miRNA from biological samples. Compared to the traditional matrix 2,5-dihydroxybenzoic acid (DHB) and previously reported oligonucleotide-specific matrices, such as 3-aminopicolinic acid (3-APA), 3-hydroxypicolinic acid (3-HPA), and 6-aza-2-thiothymine (ATT), the 3-AQ/THAP matrix offers several advantages. It produces fewer alkali metal adduct peaks, exhibits higher sensitivity, and ensures better spot-to-spot repeatability.
View Article and Find Full Text PDFEncouraging lab results bolster plans to harness a new kind of particle accelerator in x-ray sources.
View Article and Find Full Text PDFPilin antigenic variants impact gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces.
PLoS Biol
January 2025
Institute for Biological Physics, University of Cologne, Cologne, Germany.
Type 4 pili (T4P) are multifunctional filaments involved in adhesion, surface motility, biofilm formation, and horizontal gene transfer. These extracellular polymers are surface-exposed and, therefore, act as antigens. The human pathogen Neisseria gonorrhoeae uses pilin antigenic variation to escape immune surveillance, yet it is unclear how antigenic variation impacts most other functions of T4P.
View Article and Find Full Text PDFStaining Tissues with Basic Blue 7: A New Dual-Polarity Matrix for MALDI Mass Spectrometry Imaging.
Anal Chem
January 2025
Department of Chemistry, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Obtaining high-quality matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) images and the reproducibility of the technique depend strongly on the sample preparation protocol. The most crucial part is the application of the MALDI matrix, which often relies on expensive spraying or sublimation coaters. In this work, we present a new dual-polarity matrix for MALDI mass spectrometry imaging (MSI): Basic Blue 7 (BB7), which belongs to the group of triarylmethane dyes.
View Article and Find Full Text PDFBoosting Electrode Performance and Bubble Management via Direct Laser Interference Patterning.
ACS Appl Mater Interfaces
January 2025
Institute of Fluid Dynamics, Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany.
Article Synopsis
- Laser-structuring techniques, particularly Direct Laser Interference Patterning, can significantly enhance the performance of pure Ni electrodes in water electrolysis by optimizing their structure.
- A study revealed that the spatial distance between laser-structures is critical for improving electrode performance, resulting in an increase in the electrochemically active surface area by up to 12 times compared to nonstructured electrodes.
- Optimal structuring leads to lower onset potential and overpotential during the oxygen evolution reaction due to the superhydrophilic surface, which enhances bubble growth dynamics and minimizes electrode resistance.
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