AI Article Synopsis
- Galectins are glycan-binding proteins essential for various cellular functions, especially in immune and inflammatory responses.
- Galectin-11 (LGALS-11) is specifically linked to combatting gastrointestinal nematodes in animals and has shown to hinder the growth of these parasites.
- The study identifies two genetic variants of LGALS-11 in sheep, highlighting differences in their anti-parasitic abilities related to dimerization, which could inform selective breeding for parasite resistance.
Article Abstract
Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442640 | PMC |
| http://dx.doi.org/10.1038/s42003-020-01179-7 | DOI Listing |
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