Nurse leaders seek effective strategies to engage nurses in decision-making when striving for clinical excellence. When leaders cultivate safe environments, nurses are encouraged to discover new knowledge and innovations. In our institution, nurse leaders designed a systematic guide using Liberating Structures to empower nurses to develop a professional practice model.
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Microalgae-Derived Peptides: Exploring Bioactivities and Functional Food Innovations.
J Agric Food Chem
January 2025
State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, no. 1299, Sansha Road, Qingdao, Shandong Province 266404, P.R. China.
A variety of bioactive peptides with unique and diverse structures could be found in microalgae with various bioactivities including antioxidant, antihypertensive, and antibacterial bioactivities. Food products containing microalgae peptides hold significant health and nutrition potential. Peptide liberation through enzymatic and other processes enhanced protein extraction, and some animal studies were conducted to verify their health-promoting effects.
View Article and Find Full Text PDFEnhanced Anti-inflammatory Effect of Puerarin through Optimized Release and Bioavailability via PDLG-Loaded Nanoparticles.
Biol Pharm Bull
January 2025
Department of Natural products, National Institute of Pharmaceutical Education and Research (NIPER).
Puerarin (PU), a bioactive constituent reported to possess therapeutic effectiveness, but it suffers a drawback of poor bioavailability. In the present study, the PU nanoparticles (PU-NPs) were prepared using solvent-diffusion-evaporation method and optimized using Box-Behnken design (BBD), a response surface methodology for obtaining the optimal material ratio of PU-NPs. Further, PU and PU-NPs were evaluated to assess their cytotoxic effect and in vitro efficiency of inflammatory responses using lipopolysaccharide-sensitive macrophage cell line (RAW264.
View Article and Find Full Text PDFHederagenin ameliorates ferroptosis-induced damage by regulating PPARα/Nrf2/GPX4 signaling pathway in HT22 cells: An in vitro and in silico study.
Bioorg Chem
December 2024
Institute of Geriatrics, The 2nd Medical Center, China National Clinical Research Center for Geriatric Disease, Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address:
Background: Hederagenin (HG), derived from ivy seeds, is known to offer protection against Alzheimer's disease (AD). However, the specific molecular pathways through which it counters ferroptosis-induced neurotoxicity are not fully elucidated. This investigation seeks to delineate the processes by which HG mitigates neurotoxic effects in HT22 cells subjected to glutamate (Glu)-induced ferroptosis.
View Article and Find Full Text PDFA workflow to assess the recoverability of secondary raw materials via physical separation.
Waste Manag
January 2025
Helmholtz-Zentrum Dresden-Rossendorf, Helmholtz-Institute Freiberg for Resource-Technology, Freiberg, Germany.
Printed circuit boards represent an extraordinarily challenging fraction for the recycling of waste electric and electronic equipment. Due to the closely interlinked structure of the composing materials, the selective recycling of copper and closely associated precious metals from this composite material is compromised by losses during mechanical pre-processing. This problem could partially be overcome by a better understanding of the influence of particle size and shape on the recovery of finely comminuted and well-liberated metal particles during mechanical separation.
View Article and Find Full Text PDFUnlabelled: Neurodegenerative disorders, including Alzheimer's disease and AD-related dementias (AD/ADRD), pose significant challenges to health care systems globally, particularly in Africa. With the advances in medical technology and research capabilities, especially in next-generation sequencing and imaging, vast amounts of data have been generated from AD/ADRD research. Given that the greatest increase in AD/ADRD prevalence is expected to occur in Africa, it is critical to establish comprehensive bioinformatics training programs to help African scientists leverage existing data and collect additional information to untangle AD/ADRD heterogeneity in African populations.
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