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Sangiangols A and B, Two New Dolabellanes from an Indonesian Marine Soft Coral, sp. | LitMetric
A new, rare trinor-dolabellane diterpenoid, sangiangol A (), and one new dolabellane diterpenoid, sangiangol B (), together with known cembranes and dolabellanes (-), were isolated from the ethyl acetate layer of an extract of an Indonesian marine soft coral, sp. Compounds - exhibited moderate cytotoxicity against an NBT-T2 cell line (0.5-10 µg/mL). The structures of the new compounds were determined by analyzing their spectra and a molecular modelling study. A possible biosynthetic pathway for sangiangols A () and B () is presented. Cytotoxicity requires two epoxide rings or a chlorine atom, as in (stolonidiol) and (clavinflol B).
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