Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents.

Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (-). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of was established by electronic circular dichroism (ECD) calculations. Compounds and were discovered to individually reduce the generation of superoxide anions, and compound displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.