AI Article Synopsis
- Researchers isolated two compounds, epoxyjanthitrems I-IV and epoxyjanthitriol, from perennial ryegrass infected with an endophytic fungus.
- This study provides the first complete structural description of all five epoxyjanthitrem compounds using Nuclear Magnetic Resonance (NMR) techniques.
- Epoxyjanthitrem I was found to cause tremors in mice and reduce weight gain and feeding in porina pests, indicating its potential role in the effects of the AR37 endophyte on livestock and insect pests.
Article Abstract
Epoxyjanthitrems I-IV (-) and epoxyjanthitriol () were isolated from seed of perennial ryegrass () infected with the endophytic fungus var. Although structures for epoxyjanthitrems I-IV have previously been proposed in the literature, this is the first report of a full structural elucidation yielding NMR (Nuclear magnetic resonance) assignments for all five epoxyjanthitrem compounds, and additionally, it is the first isolation of epoxyjanthitriol (). Epoxyjanthitrem I induced tremors in mice and gave a dose dependent reduction in weight gain and feeding for porina (), a common pasture pest in New Zealand. These data suggest that epoxyjanthitrems are involved in the observed effects of the AR37 endophyte on livestock and insect pests.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472112 | PMC |
| http://dx.doi.org/10.3390/toxins12080526 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!