Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from , possesses strong antioxidant activity. To explore the cosmeceutical potential of fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in the present study. The anti-photoaging effect was investigated in ultraviolet (UV) B-irradiated human keratinocytes (HaCaT cells), where fucoidan effectively reduced the intracellular reactive oxygen species level and improved the viability of the UVB-irradiated cells without any cytotoxic effects. Moreover, fucoidan significantly decreased UVB-induced apoptosis in HaCaT cells by regulating the protein expression of Bax, Bcl-xL, PARP, and Caspase-3 in HaCaT cells in a concentration-dependent manner. The anti-melanogenesis effect of fucoidan was evaluated in B16F10 melanoma cells that had been stimulated with alpha-melanocyte-stimulating hormone (α-MSH), and fucoidan treatment remarkably inhibited melanin synthesis in α-MSH-stimulated B16F10 cells. Further studies indicated that fucoidan significantly suppressed the expression of tyrosinase and tyrosinase-related protein-1 and -2 (TRP-1 and-2) in B16F10 cells by down-regulating microphthalmia-associated transcription factor (MITF) through regulation of the ERK-MAPK (extracellular signal regulated kinase-mitogen activated protein kinase) pathway. Taken together, these results suggest that fucoidan isolated from possesses strong anti-photoaging and anti-melanogenesis activities and can be used as an ingredient in the pharmaceutical and cosmeceutical industries.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460018 | PMC |
| http://dx.doi.org/10.3390/md18080427 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protective effects of degraded Bletilla striata polysaccharides against UVB-induced oxidative stress in skin.
Int J Biol Macromol
October 2024
Plant Fiber Material Science Research Center, State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering, South China University of Technology, Guangzhou 510640, PR China; Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, No. 100, West Outer Ring Road, Guangzhou University Town, Panyu District, Guangzhou 510006, PR China.
The Bletilla striata polysaccharides (BSP) extracted through alkali-assisted method exhibit significant antioxidant activity, but its bioaccessibility was inadequate due to its tightly filamentous reticulation structure and high molecular weight. The anti-photoaging and anti-melanogenesis effects of degraded BSP (DBSPs) against UVB-induced oxidative stress on the skin were investigated. The molecular weights of the DBSPs were reduced to 153.
View Article and Find Full Text PDFAnti-Melanogenesis and Anti-Photoaging Effects of the Sulfated Polysaccharides Isolated from the Brown Seaweed .
Polymers (Basel)
August 2023
Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea.
Sulfated polysaccharides isolated from seaweeds are thought of as ideal ingredients in the pharmaceutical, nutraceutical, and cosmetics industries. Our previous study isolated and characterized sulfated polysaccharides from . The sulfated polysaccharides of (PBP) were extracted, and the antioxidant activity of PBP was evaluated.
View Article and Find Full Text PDFCharacterization and screening of anti-melanogenesis and anti-photoaging activity of different enzyme-assisted polysaccharide extracts from Portulaca oleracea L.
Phytomedicine
July 2023
Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address:
Article Synopsis
- Portulaca oleracea L. (PO) contains flavonoids and polysaccharides that are known for their antibacterial and antioxidant properties, but research on its effects on hyperpigmentation and photoaging is limited.
- This study focused on the anti-photoaging and skin-whitening actions of a specific polysaccharide fraction (VPOP3) from PO, which was found to have strong biological activity and was characterized for further analysis.
- VPOP3, a low-molecular-weight polysaccharide, effectively reduced reactive oxygen species and apoptosis in cells, and inhibited key proteins in melanin production, indicating its potential as a safe ingredient for cosmetic applications targeting skin aging and pigmentation issues.
Dual Skin-Whitening and Anti-wrinkle Function of Low-Molecular-Weight Fish Collagen.
J Med Food
February 2022
Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Korea.
In this study, we investigated the protective effects of low-molecular-weight fish collagen from tilapia against melanogenesis in melanocytes, ultraviolet B (UVB)-irradiated Hs27 skin fibroblasts, and hairless mice. We observed collagen production-related pathways in UVB-irradiated Hs27 skin fibroblasts and hairless mice, and the melanogenesis-related pathways in melanocyte and UVB-irradiated hairless mice. The collagen production-related pathways were activated in the UVB-irradiated Hs27 skin fibroblasts and hairless mice.
View Article and Find Full Text PDFAnti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from and Its Underlying Mechanisms.
Mar Drugs
August 2020
Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, Korea.
Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from , possesses strong antioxidant activity. To explore the cosmeceutical potential of fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in the present study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!