AI Article Synopsis
- Their structures were determined using various spectroscopic techniques and X-ray crystallography, as well as a specific chemical method called Mosher's method.
- Some isolated compounds showed strong anti-inflammatory effects by reducing nitric oxide production in certain immune cells, with inhibitory concentrations ranging from 1.3 to 41.1 μM, and their relationships in structure-activity were examined.
Article Abstract
Two new benzofurans, alternabenzofurans A and B ( and ) and two new sesquiterpenoids, alternaterpenoids A and B ( and ), along with 18 known polyketides (-), were isolated from the marine-derived fungus sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher's method. Compounds , , , , -, and - exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC values in the range from 1.3 to 41.1 μM. Structure-activity relationships of the secondary metabolites were discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460390 | PMC |
| http://dx.doi.org/10.3390/md18080426 | DOI Listing |
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