Leptospirosis is a bacterial cause for nongranulomatous uveitis in tropical countries. It is known to cause rapid maturation of cataract in young adults. Here we present six patients who had presenting sign as fully matured pearly white unilateral cataract without history of any trauma in their first visit. All except one patient were positive for leptospirosis by ELISA testing. Histopathological analyses of those lenses showed globular degeneration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690476 | PMC |
| http://dx.doi.org/10.4103/ijo.IJO_535_20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An overview of oral bioavailability enhancement through self- emulsifying drug delivery systems.
Expert Opin Drug Deliv
March 2025
Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Introduction: The pharmaceutical technologists face a lot of challenges and limitations when designing novel drug delivery systems such as low oral bioavailability of many drugs, primarily due to poor solubility, slow dissolution rates, limited permeability through gastrointestinal mucosa, and rapid degradation within the body. Areas covered: The biopharmaceutical classification (BCS) classification represents a map in drug delivery research. Numerous active ingredients are characterized by low bioavailability due to poor water solubility, especially active ingredients of BCS class II and IV.
View Article and Find Full Text PDFRelevance of Milk Composition to Human Longitudinal Growth from Infancy Through Puberty: Facts and Controversies.
Nutrients
February 2025
School of Kinesiology, The University of Michigan, Ann Arbor, MI 48104, USA.
Milk is the principal nutrient of newborn humans and a diagnostic feature of the order Mammalia. Its release is elicited as a reflex by infant sucking under the control of the hormone oxytocin. While it is recognized that breast milk optimally promotes infant longitudinal growth and development, this review explores facts and controversies regarding the extent to which the milks of several dairy animals and infant formula milk (IF) approximate special properties and bioactivities of breast milk.
View Article and Find Full Text PDFThe cellular compartment of the adult rodent subependymal zone (SEZ)-neurogenic niche is the most active regenerative area of the brain and of great interest to the regenerative medicine field. It is complex and highly heterogeneous, including neural stem cells (NSCs) in different states of activation, rapid-amplifying progenitors, immature neuroblasts (NBs), mature neurons and other non-neurogenic populations. This chapter provides a step-by-step overview of a versatile flow cytometry-based protocol, which has been molecularly and functionally validated to classify and isolate the complete neurogenic lineage, including three NSC fractions (quiescent, primed, and activated), without the need for reporter mice.
View Article and Find Full Text PDFRapid Development of Unclassified Myeloid Lineage Acute Leukaemia With Trisomy 6 and U2AF1 Mutation.
J Cell Mol Med
March 2025
Faculty of Medicine, Division of Laboratory Medicine, Medical University of Gdansk, Gdansk, Poland.
We present a case of acute clonal bone marrow 98% infiltration of atypical myeloid cells with borderline hypogranular/agranular promyelocytes/myelocytes and occasional blast cells maturity, which also formed extramedullary tumours in the chest wall, with isolated trisomy of chromosome 6 and pathogenic variant U2AF1 (S34F) that escapes established acute myeloid leukaemia (AML) diagnostic criteria according to the World Health Organization (WHO) classification. Following standard daunorubicin and cytarabine induction therapy, the disease progressed with the appearance of a previously undetected clone of leukaemic cells with a distinct immunophenotype demonstrating monocytoid differentiation and clonal evolution to a hypo-tetraploid karyotype with an average number of 84 chromosomes and new pathogenic NRAS and ZRSR2 mutations. The patient reactivated refractory disseminated intravascular coagulation (DIC) leading to a progressive supratentorial hematoma and finally cardiac arrest.
View Article and Find Full Text PDFFrontostriatal Networks Undergo Functional Specialization During Adolescence that Follows a Ventral-Dorsal Gradient: Developmental Trajectories and Longitudinal Associations.
J Neurosci
March 2025
University of Minnesota-Twin Cities Department of Psychology, Elliot Hall, 75 E River Road, Minneapolis, MN.
Seminal studies in animal neuroscience demonstrate that frontostriatal circuits exhibit a ventral-dorsal functional gradient to integrate neural functions related to reward processing and cognitive control. Prominent neurodevelopmental models posit that heightened reward-seeking and risk-taking during adolescence result from maturational imbalances between frontostriatal neural systems underlying reward processing and cognitive control. The present study investigated whether the development of ventral (VS) and dorsal (DS) striatal resting-state connectivity (rsFC) networks along this proposed functional gradient relates to putative imbalances between reward and executive systems posited by a dual neural systems theory of adolescent development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!