Deaths from cholera in Soho, London (late July to end of September 1854) exposed the epidemiology of the disease and demonstrated applied geospatial analysis by highlighting the shortest path principle followed by local residents when they obtained drinking water from a contaminated pump. The present investigation explores if households and individuals with different demographic and socio-economic characteristics were more or less likely to obtain their water from the pump and succumb to the disease. It combines information from the 1851 Population Census and topographic databases with the digital deaths and water pump data to reveal the risk of exposure and the mortality rate were greater for certain occupations, age groups and people living at high residential density irrespective of proximity to the contaminated water pump.
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http://dx.doi.org/10.1016/j.healthplace.2020.102402 | DOI Listing |
Water Res X
May 2025
Department of Civil, Architectural and Environmental Engineering, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy.
Pumps in Water Distribution Networks (WDNs) adequately provide effective pressure where low elevation or high head losses are detected within the system. One of the most effective strategies to ensure economic sustainability is Pump Scheduling (PS), assuring the optimization of pump management and enabling significant energy cost saving. Meta-heuristic algorithms can be applied to Pump Scheduling, given their ability to provide reliable global solutions, further complemented by limited computational efforts.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia.
As a promising candidate for tackling drug-resistant cancers, triptolide, a diterpenoid derived from the Chinese medicinal plant Tripterygium wilfordii, has been developed. This review summarizes potential antitumor activities, including the suppression of RNA polymerase II, the suppression of heat shock proteins (HSP70 and HSP90), and the blockade of NF-kB signalling. Triptolide is the first known compound to target cancer cells specifically but spare normal cells, and it has success in treating cancers that are difficult to treat, including pancreatic, breast, and lung cancers.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Department of Agricultural Machinery Engineering, Graduate School, Chungnam National University, Daejeon 34134, Republic of Korea.
Information and communication technology (ICT) components, especially actuators in automated irrigation systems, are essential for managing precise irrigation and optimal soil moisture, enhancing orchard growth and yield. However, actuator malfunctions can lead to inefficient irrigation, resulting in water imbalances that impact crop health and reduce productivity. The objective of this study was to develop a signal processing technique to detect potential malfunctions based on the power consumption level and operating status of actuators for an automated orchard irrigation system.
View Article and Find Full Text PDFMicroorganisms
January 2025
Department of Biochemistry and Microbiology, University of Zululand, Richards Bay 3886, South Africa.
The challenges of antimicrobial resistance (AMR) to human health have pushed for the discovery of a new antibiotics agent from natural products. Cyanobacteria are oxygen-producing photosynthetic prokaryotes found in a variety of water habitats. Secondary metabolites are produced by cyanobacteria to survive extreme environmental stress factors, including microbial competition.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Department of Molecular Microbiology and Immunology, Institute of Science Tokyo, Tokyo 113-8510, Japan.
, known for carrying the gene and linked to various diseases, is widely distributed. However, its prevalence in Ghana is unknown, mainly due to misidentification or inadequate research. In this study, for the first time, we characterized from Densu river water in Ghana.
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