AI Article Synopsis
- - Tendon is a dense connective tissue with low turnover but can grow when subjected to stress, mainly at its edges.
- - Injuries to tendons are common in sports, and it’s unclear why certain tendon areas are more prone to damage, possibly due to differences in the extracellular matrix (ECM) or turnover rates.
- - A study found that tenocytes from the core and periphery of equine superficial digital flexor tendons had similar growth rates and proteome profiles, but varied in collagen type I production, suggesting other factors influence tendon injury response.
Article Abstract
Tendon is a highly organized, dense connective tissue that has been demonstrated to have very little turnover. In spite of the low turnover, tendon can grow in response to loading, which may take place primarily at the periphery. Tendon injuries and recurrence of injuries are common in both humans and animals in sports. It is unclear why some areas of the tendon are more susceptible to such injuries and whether this is due to intrinsic regional differences in extracellular matrix (ECM) production or tissue turnover. This study aimed to compare populations of tenocytes derived from the tendon core and periphery. Tenocytes were isolated from equine superficial digital flexor tendons (SDFTs), and the proliferation capacity was determined. ECM production was characterized by immuno- and histological staining and by liquid chromatography-mass spectrometry-based proteomics. Core and periphery SDFT cultures exhibited comparable proliferation rates and had very similar proteome profiles, but showed biological variation in collagen type I deposition. In conclusion, the intrinsic properties of tenocytes from different regions of the tendon are very similar, and other factors in the tissue may contribute to how specific areas respond to loading or injury.
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| http://dx.doi.org/10.1021/acs.jproteome.0c00591 | DOI Listing |
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