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Evaluation of Clinicopathologic Features of Patients Diagnosed with Atypical Glandula Cells in Cervical Cytology. | LitMetric

Evaluation of Clinicopathologic Features of Patients Diagnosed with Atypical Glandula Cells in Cervical Cytology.

Medeni Med J

Eskisehir Osmangazi University, School of Medicine, Department of Gynocology and Obstetrics, Eskisehir, Turkey.

Published: September 2019

AI Article Synopsis

  • The study reviewed the medical records of 9,375 patients to evaluate the clinicopathologic features of those diagnosed with atypical glandular cells on cervical cytology, finding that 73 patients (0.8%) had this diagnosis.
  • Out of the patients with atypical glandular cells, 35.6% had abnormal histological findings, with significant issues including cervical lesions and invasive cancers, particularly among patients aged 50 and older.
  • The researchers concluded that 12.3% of patients with atypical glandular cells had invasive cancer, underlining the importance of thorough clinical evaluation for these patients.

Article Abstract

Objective: In our study we aimed to evaluate the clinicopathologic features of patients diagnosed with atyipcal glandular cells on cervical cytology.

Method: The records of 9375 patients who were examined in the gynecology outpatient clinic between 2010 and 2018 and underwent cervicovaginal smear were retrospectively reviewed. Seventy-three (0.8%) patients were diagnosed as atypical glandular cells. Colposcopic examination, cervical biopsy, endocervical and endometrial curettage were performed in patients diagnosed with atypical glandular cells. Age, gravida, parity, systemic diseases and clinicopathological features of the patients were examined and recorded.

Results: Cervical and endometrial abnormal histological findings were detected in 26 (35.6%) of 73 patients with atypical glandular cells. Of these 26 patients, 14 (19.1%) had cervical intraepithelial lesions, 3 (4.1%) had endometrial hyperplasia and 9 (12.3%) had invasive cancer. Five (6.8%) of the 9 patients with the diagnosis of invasive cancer had adenocarcinoma (endocervical and endometrial), in 3 (4.1%) patients cervical squamous carcinoma, and in 1 patient. endocervical lymphoma was observed.The majority of cancers detected in our study were in the age group of 50 years and older.

Conclusion: Invasive cancer is seen in 12.3% of the patients diagnosed with atypical glandular cells, and most of these patients are 50 years or older. Therefore patients diagnosed with atypical glandular cell in cervicovaginal smear should be carefully evaluated with all clinical features.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433728PMC
http://dx.doi.org/10.5222/MMJ.2019.55476DOI Listing

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