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Sirolimus-eluting stents: opposite effects on the clonogenic cell potential on a long-term exposure. | LitMetric

AI Article Synopsis

  • * When treated with sirolimus, WPMY-1 cells showed increased survival, while U2OS cells experienced a decrease in colony formation, indicating sirolimus has varying effects on different cell lines.
  • * The study concluded that while sirolimus has a known ability to inhibit cell growth, its effectiveness can differ based on the type of cells involved, which may influence the outcomes of stents used in medical practice.

Article Abstract

We evaluated the long-term effects of sirolimus on three different cell models, cultured in physiological conditions mimicking sirolimus-eluted stent, in order to clarify the effectiveness of sirolimus in blocking cell proliferation and survival. Three cells lines (WPMY-1 myofibroblasts, HT-29 colorectal adenocarcinoma, and U2OS osteosarcoma) were selected and growth in 10 ml of Minimum Essential Medium for 5 weeks with serial dilutions of sirolimus. The number of colonies and the number of cells per colony were counted. As main result, the number of WPMY-1 surviving colonies increased in a dose-dependent manner when treated with sirolimus ( = 0.0011), while the number of U2OS colonies progressively decreased ( = 0.0011). The clonal capacity of HT-29 was not modified by the exposure to sirolimus ( = 0.6679). In conclusion sirolimus showed the well-known cytostatic effect, but with an effect on clonogenic potential different among the different cell types. In the practice, the plaque typology and composition may influence the response to sirolimus and thus the effectiveness of eluted stent.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415404PMC
http://dx.doi.org/10.18632/oncotarget.27554DOI Listing

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