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Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy in Alzheimer's disease mouse models.
Biochim Biophys Acta Mol Basis Dis
October 2024
School of Physical Education, Xizang Minzu University, Xianyang 712082, Shanxi, China.
AD is the abbreviation for Alzheimer's Disease, which is a neurodegenerative disorder that features progressive dysfunction in cognition. Previous research has reported that mitophagy impairment and mitochondrial dysfunction have been crucial factors in the AD's pathogenesis. More recently, literature has emerged which offers findings suggesting that the nicotinamide adenine dinucleotide (short for NAD) augmentation eliminates the defective mitochondria and restores mitophagy.
View Article and Find Full Text PDFLamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway.
Nucleic Acids Res
September 2022
Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.
Article Synopsis
- Mutations in the lamin A/C gene cause diseases like Hutchinson Gilford progeria syndrome (HGPS) and are linked to various cancers, yet their mechanisms are not well understood.
- Research shows that lamin A/C-deficient mouse cells and human HGPS cells have low NAD+ levels and mitochondrial problems, leading to reduced mitochondrial function and energy production.
- The study identifies that lamin A/C influences mitochondrial health by affecting the recruitment of PGC1α and the NAMPT-NAD+ pathway, illuminating potential connections between laminopathies and aging.
Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1 Signaling Pathways Mediated by the NAMPT-NAD Pathway.
Oxid Med Cell Longev
May 2021
Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Background: Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances and prominent drugs seem to be of value for ischemic stroke in the clinic yet. In the previous study, notoginseng leaf triterpenes (PNGL) from notoginseng stem and leaf have been confirmed to have neuroprotective effects against mitochondrial damages caused by cerebral ischemia .
View Article and Find Full Text PDFExogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway.
Nucleic Acids Res
December 2019
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei 430062, China.
Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells.
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