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[Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes]. | LitMetric

AI Article Synopsis

  • Mammalian oocytes in Graafian follicles are held in prophase I of meiosis due to C-type natriuretic peptide (NPPC) which binds to NPR2 receptors, generating cGMP.
  • The regulation of meiotic arrest also involves factors like cAMP, gap junctions, and inosine monophosphate dehydrogenase (IMPDH).
  • Luteinizing hormone (LH) triggers a decrease in cGMP, allowing the oocyte to resume meiosis, and the paper discusses recent discoveries regarding these processes and their implications for reproductive health.

Article Abstract

Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.

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