The author addresses the essential aspects regarding the definition of the paternal function in metapsychological terms: how it forms and develops in the mental world, which functions it serves, or could come to serve, in the dynamic of mental functioning, and lastly, the consequent clinical implications, in particular the formation and development of symbolic capacity. In the second part, using two clinical vignettes and a clinical case, the author attempts to discuss its link to the theme of masculinity, suggesting a brief reflection on the challenges presented to the specificities of the analytical clinic.
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http://dx.doi.org/10.1057/s11231-020-09262-y | DOI Listing |
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Epigenetics is the link between the genome and environment, which can respond to physiological (such as age) or environmental factors (such as diet, stress, and pollution) and induce changes in epigenetic modifications (such as DNA methylation, non-coding RNA, and histone modifications). It can also serve as cellular memory transmitted from generation to generation. Sperm is highly responsive to such environmental changes and has unique epigenetic profiles.
View Article and Find Full Text PDFPaediatr Perinat Epidemiol
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Background: The relationship between maternal obesity and childhood cognitive development remains unclear. Prior studies did not adjust for important confounders, and preterm infants are a developmentally distinct group that remains scarcely examined.
Objectives: To determine whether maternal prepregnancy body mass index (BMI) is associated with offspring intelligence quotient (IQ) up to 5 years and whether this relationship varies with gestational age.
PLoS One
January 2025
Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Background: Studies have reported that pregnancies conceived by fathers with modifiable cardiovascular risk factors are at higher risk of ending in losses compared to those without such risk factors. Our objective was to examine the association between paternal family history _a non-modifiable risk factor_ of premature atherosclerotic disease and perinatal death.
Methods: This is a population-based cohort study.
Nat Commun
January 2025
Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland.
In the germ line and during early embryogenesis, DNA methylation (DNAme) undergoes global erasure and re-establishment to support germ cell and embryonic development. While DNAme acquisition during male germ cell development is essential for setting genomic DNA methylation imprints, other intergenerational roles for paternal DNAme in defining embryonic chromatin are unknown. Through conditional gene deletion of the de novo DNA methyltransferases Dnmt3a and/or Dnmt3b, we observe that DNMT3A primarily safeguards against DNA hypomethylation in undifferentiated spermatogonia, while DNMT3B catalyzes de novo DNAme during spermatogonial differentiation.
View Article and Find Full Text PDFProc Biol Sci
January 2025
Centre for Evolutionary Biology, School of Biological Sciences, University of Western Australia, Crawley, Australia.
Sperm are traditionally viewed as transcriptionally and translationally silent cells. However, observations that components of the cellular machinery of gene expression are maintained in ejaculated sperm are increasingly cited as challenges to this fundamental assumption. Here, we critically evaluate these arguments and present three lines of evidence from both model and non-model systems that collectively raise the question of whether ejaculated sperm may be capable of active gene expression.
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